Scientist

Company : Sigma Inc

Scientist—Solid-State NMR | Ridgefield, CT | 12-Month Contract

Job ID: (phone number removed)
Location: Ridgefield, CT (Onsite)
Contract Length: 12 Months

Sigma Inc. is seeking an innovative and detail-oriented Scientist with strong expertise in solid-state NMR (ssNMR) spectroscopy to join our team in Ridgefield, CT. This role offers the opportunity to contribute directly to the discovery, development, and delivery of pharmaceutical products while collaborating with a global network of scientists.

We foster a collaborative work culture focused on meaningful science, diversity and inclusion, career mobility, and work-life balance.

Key Responsibilities

• Apply solid-state NMR (ssNMR) spectroscopy to acquire and interpret multinuclear data (¹H, ¹ F, ¹³C, ¹ N, etc.) for molecular structure elucidation.

• Characterize pharmaceutical materials (particles, powders, suspensions, APIs, excipients, intermediates, drug products).

• Use quantitative ssNMR methods to measure drug components and ensure product quality.

• Integrate molecular modeling, solution NMR, and X-ray crystallography for 3D structural evaluation.

• Prepare and troubleshoot ssNMR experiments, including Bruker ssNMR probe changes.

• Ensure proper data backup, retrieval, and detailed technical reporting.

• Stay current with scientific literature and contribute to the design and execution of new experiments.

• Present findings at internal scientific meetings and collaborate with multidisciplinary teams.

Required Qualifications

• Master’s degree in Organic Chemistry or related field.

• 1–3 years of hands-on solid-state NMR spectroscopy experience in pharmaceutical R&D.

• Strong background in solution NMR for structure elucidation.

• Experience with sample preparation, data acquisition, and interpretation of multinuclear NMR data.

• Ability to implement and troubleshoot ssNMR experiments and operate Bruker ssNMR systems.

• Solid understanding of molecular structure, interatomic distances, hydrogen bonding, torsion strain, and interactions.

• Excellent oral/written communication, laboratory safety practices, and record keeping.

Preferred Qualifications

• Experience with computational modeling (qm-DFT, Monte Carlo, Gaussian, Schrodinger, Materials Studio, CCDC software).

• Familiarity with Linux/HPC clusters for molecular simulations.

• Background in membrane protein sample preparation and biological applications of ssNMR.

• Prior collaboration within diverse, cross-functional scientific teams.

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