Associate Scientist, Biochemistry
Website Civetta Therapeutics
Company : Civetta Therapeutics
Country: United States
Location : Cambridge, Massachusetts
Post: Mon, 20 Sep 2021 06:29:46 GMT
Expires: Mon, 18 Oct 2021 23:59:59 GMT
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—————————— Job Description ——————————
Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through the targeting of beta-propeller domain proteins. Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases. Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients.
We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer. If you are an accomplished life sciences professional that can bring significant energy, passion and expertise to the team, we welcome the opportunity to consider you for a position.
The position. We are seeking an exceptional and motivated biochemist to help us discover small molecule modulators of beta-propeller proteins, to support validation of new targets, and to help propel our ongoing drug discovery programs. This is an excellent opportunity for individuals looking to work in a fast-paced, dynamic biotech environment.
Design and perform biochemistry/biophysical experiments to investigate protein:protein interactions using FRET, TR-FRET, HTRF, AlphaScreen, and fluorescence polarization assays
Collaborate with colleagues in protein sciences, cell biology, chemistry, and chemical biology to characterize beta-propeller protein interactions with small molecule ligands
Employ mechanistic studies to determine the mode-of-action for promising hits and lead compounds
Provide analysis, interpretation and communication of high-quality data
PhD in Biochemistry or related field with 2 years related experience in a biotech/pharma setting; or BS/MS with a minimum of 8 years of comparable relevant experience in drug discovery in an industry setting
Experience working with protein interactions and multi-protein complexes
Experience with FRET, TR-FRET, HTRF, AlphaScreen, fluorescence polarization and thermal shift assay formats
Familiarity with general cell biology techniques including interaction and proximity-based assays, immunoprecipitations, Western blotting
Experience working with small molecule compounds using liquid handling and lab automation is highly desired
Understanding of disease biology and associated signaling pathways is desired
Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, CROs, and scientific advisors
Highly organized with excellent analytical, documentation and multi-tasking skills
Enthusiastic, self-motivated individual wanting to work in the fast-paced and dynamic environment of a startup
Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.
Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to (url removed), and we will contact you if needed.
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