Website Katalyst Healthcares & Life Sciences
Katalyst Healthcares & Life Sciences
Company : Katalyst Healthcares & Life Sciences
Job Description:
The Quantitative, Translational ADME Sciences (QTAS) department at client is seeking a highly motivated and energetic bioanalytical scientist to join the biologics bioanalysis, characterization, and proteomics (BBCP) group. The primary responsibility of this position is to support LC-MS (liquid chromatography-mass spectrometry)-based bioanalysis and method development for biologic entities, such as monoclonal antibodies, multi-specific antibodies, antibody-drug conjugates (ADCs), and other Client modalities. The successful candidate will have experience in optimizing and implementing hybrid LC-MS-based bioanalytical methods to support non-regulated preclinical PK and TK studies. Responsibilities include routine sample preparation, method development, instrument maintenance, data analysis, report writing, and presenting data at internal and external meetings.
Responsibilities:
- Perform affinity purification and digestion of biological therapeutics (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices manually or using automation systems.
- Operate and maintain LC/MS instruments to generate high-quality experimental data.
- Optimize and develop LC/MS methods to meet assay specificity and sensitivity requirements.
- Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
- Communicate data interpretation internally and externally.
Requirements:
- Degree in chemistry, pharmacology, or other related fields. BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry. Prior industry experience in drug discovery/development is highly desired.
- Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
- Hands-on experience with QQQ (SCIEX) is required, additional experience with qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is a plus.
- Hands-on experience with biologics bioanalysis is highly desired, additional experience with oligonucleotide analysis is a plus.
- Hands-on experience with immuno-affinity purification and automation systems (e.g., TECAN, AssayMap Bravo or Hamilton) is highly desired.
- In-depth understanding of PK, TK and PK/PD studies is preferred.
Top skills:
- Degree in chemistry, pharmacology, or other related fields. BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry. Prior industry experience in drug discovery/development is highly desired.
- Hands-on experience with QQQ (SCIEX) Mass Spectrometer is required, additional experience with qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is a plus.
- Hands-on experience with biologics bioanalysis is highly desired, additional experience with oligonucleotide analysis is a plus.
- Hands-on experience with immuno-affinity purification and automation systems (e.g., TECAN, AssayMap Bravo or Hamilton) is highly desired.
- Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.