Website The Fountain Group LLC
The Fountain Group LLC
Company : The Fountain Group LLC
The Fountain Group is currently seeking a Scientist / Senior Research Associate for a prominent client of ours. This position is located in Cambridge, MA. Details for the position are as follows:
Job Description:
100% ONSITE
JOB TITLE DETAILS:
PhD Job Title: “Scientist”
BS/MS Job Title: “Senior Research Associate”
OBJECTIVES/PURPOSE
Design and implement experiments to screen for drug candidates, and to address mechanisms-of-action of therapeutic molecules. Perform complex cell-based functional experiments independently.
Act as a subject matter expert (SME) for drug discovery in the Cell therapy and Immuno-Oncology/Immuno Therapy.
ACCOUNTABILITIES
Provide broad assay development support for early stage drug discovery projects in disease areas of the Cell therapy and Immuno-Oncology/Immuno Therapy.
Design, execute and validate a variety of assays to understand mechanism of action and characterize different biologics (e.g., mAb, T cell engagers) and cell therapy new modalities (e.g., CAR-T, CAR-NK).
Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of variable cell based assays.
CAR T/NK generation (transduction and expansion) and functional evaluation of CAR expression, phenotyping, cytokine detection and killing potency in vitro.
Spend ~ 85% of time in laboratory to maintain and implement cell based assay platform and perform experiments.
Interface with project teams to meet timelines for project progression.
Present research findings clearly and effectively at internal and external meetings.
Troubleshoot complex problems in creative and effective ways.
Qualifications:
PhD (fresh grads okay) -or- MS (2+ years of relevant professional lab) -or- BS (5+ years of relevant professional lab)
Strong immunology and oncology background (biotech/pharma preferred)
Strong tissue and NK/T cell culture experience
Relevant Skills:
Tissue culture including application of aseptic techniques for media compounding, passaging
maintenance and cryopreservation of cell cultures.
Experience with immune cell (T/NK cells) isolation, culture, and engineering.
Proficiency in immune cell phenotyping (surface/intracellular), cytokine detection (multi-color flow cytometry, Luminex, MSD), cytotoxicity assay and High content imaging (Opera Phenix) or other functional assays
Proficient in data generation (prism, excel), presentation and troubleshooting.
Experience with viral delivery methods is a plus.
Compensation: Up to $66.67 per hour