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Scientist, Neoantigen Screening

  • Permanent
  • Anywhere

Website Affinity Executive Search

Affinity Executive Search

Company : Affinity Executive Search

Country: United States

Location : Pittsburgh, Pennsylvania

Post: Fri, 10 Sep 2021 04:02:31 GMT

Expires: Sun, 10 Oct 2021 23:59:59 GMT

Apply Job : Apply Online

—————————— Job Description ——————————

My client is expanding and looking to hire a T-Cell Immunology Scientist. This person will play a key role with the ongoing development of a high throughput platform for screening T-cell receptors against neoantigen libraries.

The ideal candidate will take on the following tasks:

* Establish an efficient neoantigen screening platform
* Develop novel RNA, DNA and peptide-based technologies for HTS of T-cell receptors
* Using multicolor flow cytometry, express recombinant proteins and enzymatic fluorophore labeling for applications
* Collaborate with internal and external partners to identify and characterize oncology neoantigen libraries
* Propose, validate and lead adoptive T-cell therapy programs for new therapeutic approaches

The ideal candidate will possess the following qualities:

* PhD and strong background in molecular biology + assay development plus 2+ years of post-doc experience
* Expert on molecular biology techniques, including DNA/RNA extractions, PCR, plasmid cloning, basic bioinformatics and vector construction, transfections, including retro and lentivirus production
* Extensive tissue culture experience including cell line and primary culture techniques
* Knowledge of bioinformatic software using algorithms to predict neoantigen binding such as NetMHCpan or pVACSeek
* Experience with multi-color flow cytometry and data analysis
* Track record of T cell functionality using surface expression markers, signaling, cytokine secretion, cell based killing or proliferation assays

To apply for this job please visit www.resume-library.com.