Senior Scientist/Associate Principal Scientist, Protein Sciences

  • Permanent
  • Anywhere

Website Civetta Therapeutics

Civetta Therapeutics

Company : Civetta Therapeutics

Country: United States

Location : Cambridge, Massachusetts

Post: Mon, 20 Sep 2021 06:29:42 GMT

Expires: Mon, 18 Oct 2021 23:59:59 GMT

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—————————— Job Description ——————————

Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through the targeting of beta-propeller domain proteins.  Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases.  Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients.

We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer.  If you are an accomplished life sciences professional that can bring significant energy, passion and expertise to the team, we welcome the opportunity to consider you for a position in this exciting, new company committed to thorough, mechanistically driven science.


The position.  We are seeking an experienced and creative protein biochemist at the Senior Scientist level to propel our gene-to-structure efforts in Protein Sciences.  This position will help build world-class platform capabilities to discover small molecule modulators of beta-propeller proteins.


Key Responsibilities

Provide expertise and insight for construct design and purification protocols for protein production.

Perform expression and purification of challenging beta-propeller proteins to establish robust protocols that can be used internally or transferred to external (CRO) resources as needed.

Collaborate productively with biochemistry and biophysics colleagues to generate protein reagents for assay development targeting beta-propeller proteins and multi-protein complexes.

Assist with crystallization of protein-ligand and protein-protein complexes.

Make intellectual contributions to all stages of drug discovery and project delivery.




Ph.D. or B.S./M.S. degree with relevant experience in an industrial gene-to-structure group.

Minimum 10 years of industry experience. Civetta will explore candidates with a wide range of experience levels and title for the successful candidate will be commensurate with experience

Expertise with expression of proteins and protein complexes using multiple host systems (mammalian, insect, bacterial).


Extensive protein biochemistry experience working with challenging proteins and multi-protein complexes.

Experience using specialized purification strategies, such as HIC and refolding from inclusion bodies.

Knowledge of protein structure and experience in the preparation of high-quality, concentrated protein samples for biophysical (SPR, ITC, DSF) and structural studies (NMR, X-ray, Cryo-EM).

Experience balancing CRO and internal resources to solve problems and drive progress.

Exceptional interpersonal and communication skills, and ability to effectively present data within the company and to other stakeholders.

Adept at working effectively within motivated cross-functional scientific teams to deliver project goals within timelines.


Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.


Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to (url removed), and we will contact you if needed.








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