Senior Staff Scientist

  • Permanent
  • Anywhere

Website Bruker


Company : Bruker

Country: United States

Location : San Jose, California

Post: Sat, 30 Jul 2022 21:18:51 GMT

Expires: Sat, 27 Aug 2022 23:59:59 GMT

Apply Job : Apply Online

—————————— Job Description ——————————

Acuity Spatial Genomics, Inc. (a Bruker subsidiary) is focused on opening a new frontier in spatial 3D genomics and multiomic analyses. We are committed to the development of a novel technology platform allowing progress in genome-wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. The Company brings together the premier spatial omics approach (OligoFISSEQTM) with leading-edge imaging, data acquisition and analysis capability.  The pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single cell and sub-cellular level. We aim to find the best talent in the field to join and contribute to this extraordinary, exciting endeavor becoming a critical member of this groundbreaking opportunity.

Position description: 

The candidate will be a key contributor to optimization and development of advanced bioassays for determination of chromosome and chromatin architecture through the use of spatial omics approaches.

This is a unique multi-disciplinary position that will work closely with a variety of disciplines including Chemistry, Molecular Biology, Computational Biology, Microfluidics, Imaging and Support groups. As part of our team, you will design cutting edge approaches and experiments to map spatial gene activity and expression. You will oversee technique optimization in the leading approach to in situ imaging of gene activity, localization, and expression.

The ideal candidate should have experience working independently in a biochemistry or molecular biology assay development environment, have exceptional attention to detail, and be able to critically analyze data and communicate results to the team. They must bring a can-do attitude and sense of purpose to the job. This position must be able to independently make decisions on work direction.


Lead the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques and probe library preparation.

Work within multidisciplinary teams at all stages of product development.

Develop a deep understanding of the interplay between chemistry, molecular biology microfluidics, imaging and bioinformatics analysis to identify the root cause of product deviations, troubleshoot them, and generate creative solutions.

Independently plan and execute experiments, accurately record details, provide in-depth analysis, and report results through documentation and presentations.

Design approaches to protocols. Develop and optimize protocols for in situ spatial omics products and perform robustness verification of those products.

Responsible for development, verification and validation of product related kits and reagents.

Prepare customer-facing technical documentation including Kits and Reagents workflow descriptions and annotated instructions for company products.

Work with and guide junior associates/ scientists in their day-to-day activities.

Educational/Experience requirements:

PhD in chemistry, biochemistry, molecular biology, or related field.

5+ years relevant laboratory or industry experience in life science applications, such as: next-generation sequencing library preparation, cell culture, microscopy, PCR, or other nucleic acid or protein-based technologies.

Proven track record in development of sample handling/preparation techniques for cell culture/fresh frozen and FFPE tissue fixation, permeabilization and visualization.

Experience in developing assays using nucleic acid sequencing and hybridization techniques such as FISH.

Ability to analyze and interpret complex datasets and communicate results in a clear and concise manner.

Demonstrated ability to work in a multi-disciplinary team.

Knowledge of fluorescence markers and imaging with an understanding of basic absorption and emission spectroscopy.

Experience troubleshooting and optimizing molecular biology assays.

Proven ability to mentor and work with and guide junior associates/ scientists in their day-to-day activities.


Additional desirable skills to have:

Experience with new product introduction or product development process and life cycle.

Familiarity with basic statistical data and error analysis. Experience with Design of Experiments (DOE).

Experience with advanced fluorescence techniques and microscopy image analysis.

Experience in assay development on novel and prototype instrumentation and workflows.



The Company offers a comprehensive and competitive benefits package including medical, dental, 401(k), paid vacation, holidays, and tuition assistance (as applicable).


We are an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, veteran status, and other protected characteristics.


Certain positions at the Company require compliance with export control laws and a result, all interviewed candidates for all positions will be screened pre-interview to determine their eligibility in light of export control restrictions.



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