System Integration Senior Research Associate

  • Permanent
  • Anywhere

Website Bruker


Company : Bruker

Country: United States

Location : San Jose, California

Post: Sat, 30 Jul 2022 21:18:51 GMT

Expires: Sat, 27 Aug 2022 23:59:59 GMT

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—————————— Job Description ——————————

Acuity Spatial Genomics, Inc. (a Bruker subsidiary) is focused on opening a new frontier in spatial 3D genomics and multiomic analyses. We are committed to the development of a novel technology platform allowing progress in genome-wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. The Company brings together the premier spatial omics approach (OligoFISSEQTM) with leading-edge imaging, data acquisition and analysis capability.  The pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single cell and sub-cellular level. We aim to find the best talent in the field to join and contribute to this extraordinary, exciting endeavor becoming a critical member of this groundbreaking opportunity.

Position description: 

The candidate will be a key contributor to optimization and development of advanced bioassays for determination of chromosome and chromatin architecture through the use of spatial omics approaches.

The candidate will support the establishment of a robust assay workflow across all assay product modules.

The candidate will assist with troubleshooting, optimization, verification and validation of the assay platform, will work with system instrumentation engineers, and be a key liaison between technical teams from imaging, software, microfluidics, assay development and assay design.

The ideal candidate should have experience working independently, have exceptional attention to detail, and be able to critically analyze data and communicate results to the team. They must bring a can-do attitude and sense of purpose to the job.


Contribute to system testing across the entire product workflow and be a key partner to optimize, troubleshoot and relay system performance to the entire development team.

Work within multidisciplinary teams at all stages of product development.

Develop a deep understanding of the product workflow and platform technology.

Prepare research reports and share findings with the team. Write protocols, develop procedures, and maintain accurate records.

Clearly communicate and present results; contribute data for making critical design decisions.

Educational/Experience requirements:

BS/MS in molecular biology, biochemistry, cell biology, engineering or a related field and 3+ years of hands-on system testing in a molecular biology environment either in an academic or industrial setting.

Experience in troubleshooting and optimization of assays on molecular biology assay platforms.

Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques.

Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed-based techniques. Understanding of basic absorption and emission spectroscopy.

Highly motivated with excellent attention to detail. Good communication (oral and written) and collaboration skills.

Experience with experimental design and data analysis. Must be capable of performing complex multi-step experiments with detailed and diligent attention to technique and protocols with accurate record keeping.

Desire to be part of a rapidly evolving organization, which requires real-time communication, flexibility, working well with others, and a willingness to learn new techniques and methods.

Additional desirable skills to have:

Experience with new product introduction or product development process and life cycle.

Familiarity with basic statistical data and error analysis. Familiarity with single cell and/or spatial transcriptomics, fixation chemistry, Design of Experiments (DOE).

Experience with advanced fluorescence techniques and multi omic microscopy image analysis.

Experience in assay development on novel and prototype instrumentation and workflows.


The Company offers a comprehensive and competitive benefits package including medical, dental, 401(k), paid vacation, holidays, and tuition assistance (as applicable).


We are an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, veteran status, and other protected characteristics.


Certain positions at the Company require compliance with export control laws and a result, all interviewed candidates for all positions will be screened pre-interview to determine their eligibility in light of export control restrictions.




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