USA-Research Associate II (Scientific)
Company : Mindlance
Country: United States
Location : Cambridge, Massachusetts
Post: Sat, 01 Oct 2022 15:32:40 GMT
Expires: Sat, 29 Oct 2022 23:59:59 GMT
Apply Job : Apply Online
—————————— Job Description ——————————
note on 09/30
Manager has requested additional resumes, must have FFPE (Formalin-Fixed Paraffin-Embedded (FFPE) tissue & Immunohistochemistry (or IHC) experience. Previous top candidate had experience related to: Histology Specialist/Supervisor. Title or Research areas may offer similar skill sets.
NOTE ON 09/15
Manager has requested additional resumes: Candidates must have exp in quantitative fluorescence IHC (FIHC), FFPE (Formalin-Fixed Paraffin-Embedded) Tissue Samples.
Location is Cambridge MA. There is paid parking at this site Must have Experience: Minimum of 3 years of relevant industry experience (demonstrated abilities with handling FFPE tissue samples. Experience with techniques such as IHC/IF FIHC, FFTPE, ICF Antibody Validation Strong reporting experience, experience in risk assessment, policy changes BS in Biology Required 3 years of professional experience Nice to Have: MA Oncology preferred Exp with automated slide stainers or manual stainers GeoMx (Nanostring), Visium (10x Genomics) *Flexibility in bill rate exception will be considered for this experience*
Precision Oncology Spatial Transcriptomics Research Associate II
Job Overview/Department Description:
Precision Oncology is a dedicated Oncology Research group focused on increasing success rates in early development by applying High Content Data and Analytics to inform both Research and early Development decisions. We work as the integrated analytical arm of drug discovery teams and embrace a Bedside to Bench and Back approach to understand at the molecular level cancer subtypes, immune context, and drug response in patients. Molecular data (cytometric, single cell and spatial data) as well as advanced statistical and machine learning methods are used to identify targets, and animal models for hypothesis testing, POC indications, and biomarkers for advancing our cancer drug discovery programs.
We are seeking a self-motivated candidate with a strong background in immunochemistry, histology, and imaging to help support our effort in spatial biology. Additional technical experience in GeoMx Digital Profiler (DSP) and/or molecular biology are desirable. The successful candidate we are looking for is an independent problem-solver, detail oriented and agile. Key responsibilities include experimental design, implementation, and troubleshooting of high-multiplex spatial assays (both independently and in collaboration with colleagues). Colleague must feel comfortable presenting summarized experimental results.
1. Responsible for the execution and analysis of experiments and analytical procedures.
Handle human and non-human FFPE or FF tissue sections
Perform histologic and immunofluorescent staining of slide-based samples
Validate/optimize/troubleshoot new antibodies/panels for FIHC based assays
Perform slide preparation and data collection for transcriptional profiling of FFPE tissue sections
Prepare sample libraries for Next Generation Sequencing (NGS)
2. Display an investigative or technological orientation in designing, executing and interpreting experiments and analytical procedures with minimal guidance.
3. Investigate basic technical problems and performs routine scientific procedures and experiments under general supervision.
4. Plan and prioritize concurrent experimental procedures.
5. Integrate, compile, and tabulate data and assist supervisor in the analysis and interpretation of the results.
6. May provide oral presentations on results to other department members.
Masters degree (preferred) or bachelors degree in biology or related discipline
Minimum of 3 years of relevant industry experience (demonstrated abilities with handling FFPE tissue samples. Experience with techniques such as IHC/IF, imaging, histology required)
Self-motivated and organized with attention to detail and ability to multi-task
Excellent communication and time-management skills
Strong written and spoken English skills
Familiarity with common computer programs (MS Word, Excel and PowerPoint)
Familiarity with drafting protocols and presenting scientific results
Attention to detail and organization
Good problem-solving abilities
Strong interpersonal communication and capacity to work as part of a team
Flexibility, adjusting to a fast-paced, goal-oriented environment and willingness to expand and broaden skillset.
Experience with antibody validation, optimization and troubleshooting for FIHC is preferred
Experience in automated slide stainers like Leica Bond Rx is preferred
Experience on implementing one of the currently available spatial transcriptomics technologies such as GeoMx (Nanostring), Visium (10x Genomics), or other similar platforms is preferred
Experience with next generation sequencing techniques is preferred
Experience in image analysis software like HALO, Visiopharm, ImageJ is preferred
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