Associate Scientist, Drug Metabolism Pharmacokinetics, BA, MDC

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Company :
Eisai US

Location :
Cambridge, Massachusetts

Expiry Date :
Wed, 07 Apr 2021 23:59:59 GMT

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Description :
At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai’s human health care (hhc) mission. We’re a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world’s most widely-used treatment for Alzheimer’s disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you. Job Summary The primary role of the Associate Scientist, DMPK (Drug Metabolism Pharmacokinetics) is a highly qualified multi-disciplinary team-oriented researcher with emphasis in the area of cell-based permeability, drug transport and disposition with experience in bioanalytical and laboratory automation technologies. The major role of this position would be responsible for developing bioanalytical methods and conducting in vitro ADME studies to support discovery projects. Additional duty will include workflow logistics, such as interaction with internal/external collaborators, track study status, review data and upload data into database. Essential Functions – Develop robust bioanalytical methods for in vitro ADME studies and in vivo study samples using LC-MS/MS. Operate and maintain instruments independently with adequate ability of troubleshooting. – Conduct various in vitro ADME experiments, including but not limited to stability studies using microsomes, hepatocytes and/or tissue homogenate, plasma and/or tissue protein binding, blood to plasma ratio, CYP inhibition/TDI, and reaction phenotyping. – Analyze raw data and report deliverables including relevant parameters for in vitro ADME and in vivo PK assays in a timely fashion. – Communicate research results to supervisor and project managers, process data, summarize in report format and upload into database in a timely manner. – Maintain laboratory notebook and complete all documentation according to the standard operating procedures. – Involve in comprehensive mechanistic ADME studies and author scientific manuscript for publication purpose as needed. – Maintain smooth workflow with internal/external collaborators including track study status, review and audit data and upload data into database. – Contribute to preparation and submission of patents and scientific publications and regulatory documents as needed Requirements – B.S. in Biology, Chemistry, Pharmaceutical Sciences or other related field with over 3 years’ experience or M.S. with 0-2 years of experience in industrial or relevant field. – Hands on experience and knowledge with in vitro ADME studies and analytical techniques (UPLC/HLPC and Triple Quad/TOF Mass Spectrometry). – Experience in using non-compartmental PK analysis is a plus.Familiar with laboratory automation (Hamilton) and liquid handling equipment is a plus. – Familiar with standard data analysis software packages used in the industry such as Excel, GraphPad, Phoenix or other similar software packages. – Familiar with electronic notebooks. – Mechanistic DMPK knowledge background is a plus. – Ideal candidate should be someone who is self-motivated, eager to explore and learn new skills, and is able to work productively in a team environment. – Excellent problem solving, organizational and documentation skills, and strong oral and written communication skills. Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, Eisai prohibits discrimination against persons because of disability, including disabled veterans. Please Click On The Following Link For More Information Eisai Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States. Right To Work E-Verify Participation