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BFT Research Technician for MGH Dermatology Research Laboratory!

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Company :
Massachusetts General Hospital (MGH)

Location :
Boston, Massachusetts

Expiry Date :
Mon, 08 Mar 2021 23:59:59 GMT

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Description :
Employer Name: SpiderID: Location: Boston, Massachusetts Date Posted: 2/4/2021 Wage: Negotiable Category: Law Enforcement/Security/Safety Job Code: -1421 Job Description: Research technician position in Angiogenesis/Immunology/Wound healing at Harvard/MGH Laboratory of Angiogenesis and Inflammation, Dr. Alexander G. Marneros, Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Boston Our laboratory is investigating molecular mechanisms involved in wound healing, angiogenesis and inflammation. Please note this position is temporary in nature and not eligible for benefits. Project 1: We are investigating molecular mechanisms that control macrophage activation and the role that activated macrophages play for inflammation and pathological angiogenesis. We have established in vitro assays to identify regulators of macrophage polarization. In chemical screens we could identify pharmacologic inhibitors of alternative macrophage polarization (M2-type macrophages) and could show in vivo that these inhibitors can block macrophage-induced angiogenesis (Cell Reports, 2013; JBC, 2014; Am J Path, 2013, 2014, 2016). This project aims to define molecular pathways that are critical for macrophage polarization and that influence the ability of activated macrophages to induce pathological angiogenesis in conditions such as age-related macular degeneration, cancer or wound healing. Project 2: We investigate the role of proangiogenic factors for wound healing and age-related diseases. We could show that the proangiogenic factor VEGF-A induces oxidative stress and NLRP3 inflammasome activation to promote age-related diseases (Cell Reports, 2013; FASEB J, 2014; EMBO Mol Med, 2016; FASEB J, 2018, eLife, 2020). We use a variety of in vivo and in vitro approaches to investigate a novel pathogenic link between VEGF-A and NLRP3 inflammasome activation. Project 3: We identified a novel pathway that is critical for epithelial differentiation, especially in the kidney. This AP-2b/KCTD1 pathway plays a critical role in kidney development and for renal function in the adult. We use mouse genetics to elucidate the role of this pathway for kidney functions (Dev Cell, 2020; Cell Reports, 2021). In summary, our laboratory uses a large number of diverse experimental approaches (human genetics, mouse genetics, chemical screens, in vitro assays, cutting-edge imaging technology) to define novel mechanisms in angiogenesis, wound healing and inflammation. All of our projects have strong translational clinical relevance. Our laboratory is embedded in a highly productive and well-equipped environment at the Cutaneous Biology Research Center of Massachusetts General Hospital/Harvard Medical School. Cutting-edge technologies are available within our Department and the MGH/Harvard research community. Qualifications Required profile: – Passionate about science and commitment for ~1 year required – prior laboratory experience, especially working with mice, preferred – applicants must be reliable, well organized and have good log-keeping abilities – BA/BS/MS degree preferred – Position start date: ASAP lab website: Interested candidates should send the CV and references to Alexander G. Marneros, M.D., Ph.D., Email: EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. Partner’s Healthcare is acting as an Employment Agency in relation to this vacancy. Job Criteria: Start Date: Position Type: Full-Time Permanent Years of Experience Required: Education Required: Overnight Travel: Vacation Time: Contact Information: Contact Name: Partner’s Healthcare Company Type: Company: Massachusetts General Hospital(MGH) City: State: Zip: