IGM Research Assistant

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Company :
Nationwide Childrens Hospital

Location :
Columbus, Ohio

Expiry Date :
Sat, 17 Apr 2021 23:59:59 GMT

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Description :
Job Details Full-time1 hour ago Qualifications – Laboratory experience – Research – Bachelor’s degree Full Job Description Overview: Translational Neuroscience, Human iPS Cells, Brain Organoids, 3D Bioprinting, 3D Imaging, Multi-Electrode Array Electrophysiology, Neural Circuitry Modeling, OMICs Technologies, Genome Editing, Bioengineering, Molecular Mechanisms of Epilepsy, Brain Injury, and Autism. The Hester Lab is accepting applications for a Research Assistant (applicants with a BS from backgrounds either in Neuroscience, Biomedical or Tissue Engineering, or Molecular, Cellular, and Developmental Biology will be considered, itional backgrounds in Genomics/Bioinformatics/Statistics is a plus). Our team is part of the Institute for Genomic Medicine (IGM) at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, which is at the forefront of using genomic sequencing in the clinical setting to predict best health outcomes for patients and is one of the driving forces shaping precision medicine. Led by a team of internationally-renowned genomic medicine scientists, IGM is housed in the campus’ newest research building, spanning ~25,000 square feet of laboratory and office space in a highly interactive setting. Our passion and vision is to rapidly translate research discoveries into lasting treatment options for pediatric patients afflicted with neurological disease. We utilize a multidisciplinary approach in our research that encompasses genomic medicine, neuroscience, stem cell biology, biochemistry and molecular genetics to investigate the dynamic nature of the developing mammalian brain both in the context of disease and injury and under normal physiology. There have been major advances in identifying the genetic basis of neurodevelopmental disorders such as autism and pediatric epilepsy. However, a critical knowledge gap still remains, how do genetic mutations contribute to the molecular mechanisms involved in these complex disorders? To ress this knowledge gap, our team is leveraging several key technological tools that include the use of: human brain organoid models, genome editing tools, OMICs technologies, and the use of novel transgenic mouse models to move the field forward in autism and pediatric epilepsy research. We are using these innovative tools as a platform to test our hypotheses for understanding how gene mutations contribute to the molecular mechanisms that drive the pathogenesis of these neurological disorders. The long-term goal of our research program is to identify molecular mechanisms of neurodevelopmental disorders that will allow us to develop targeted therapies to improve health outcomes and quality of life for pediatric patients. A central area of research emphasis is to develop advanced high content imaging platforms to analyze complex deep phenotypes in diseased human cerebral organoids for screening and identification of potential therapeutic candidates. Ultimately, the passion and vision of the Hester Lab is to rapidly translate research discoveries into lasting treatment options for pediatric patients afflicted with neurological disease. If you this passion and vision, please send your CV, a cover letter, names of 3 references with contact information, and a one page statement of your research interests to Please include ‘Translational Neuroscience Research Assistant Position’ in the subject line. Competitive applications will be evaluated when they are received and the position will remain open until the position is filled. Why Nationwide Children’s Hospital?: The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Children’s Hospital, where Passion Meets Purpose. Here, Everyone Matters. We’re 12,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world we’ll never even meet. Kids who are living healthier, fuller lives because of the knowledge we . We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere. Ask anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere. Nationwide Children’s Hospital. A Place to Be Proud Responsibilities: Cell culture of neurons and astrocytes 3-D organoid cultures Electrophysiological analysis of organoids Cryostat sectioning of brain tissue Immunohistochemistry Confocal microscopy Qualifications: Bachelor of Science degree with two to three years of laboratory research experience OR certification and experience may be considered in lieu of formal education. Laboratory experience preferred Coursework in anatomy, physiology, statistics, relevant research methods and radiation desirable. Percent of time spent on: 50% Preparing test substrates, conducting assays, preparing cultures 25% Interpreting results of data analyses with PI 11% Miscellaneous paperwork associated with research 10% Ordering supplies 02% Preparation of budget 02% Instructing other lab personnel Minimum physical requirements: 100% Kneeling / reaching 100% Finger dexterity 100% Talking / hearing / seeing 33% Lifting / carrying weight 0-20 pounds for 1-5 minutes The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individual so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under his/her supervision. EOE M/F/Disability/Vet Apply Now