In Vivo Pharmacology Research Scientist
Expiry Date :
Sun, 06 Dec 2020 23:59:59 GMT
Apply Job :
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. In Vivo Pharmacology Research Scientist The new Bristol-Myers Squibb research site in Cambridges Kendall Square will help us continue to deliver on our mission, positioningthe company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities. The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. We are seeking an In Vivo Pharmacology Research Scientist to join the Oncology Discovery Pharmacology and In Vivo Biology group within the Mechanisms of Cancer Resistance (MoCR) organization at Bristol-Myers Squibb Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative bench scientist who will conduct experiments utilizing tumor xenograft and genetically engineered mouse models to advance oncology discovery programs into the clinic. The successful candidate will demonstrate clear and professional communication, effectively collaborate with colleagues across a highly matrixed environment, and be capable of presenting scientific results to project teams. Qualifications & Responsibilities – A B.S. with 7+ years or a M.S. with 4+ years of relevant industry experience and a clearly demonstrated skill set in in vivo oncology is required. This is not a PhD role. – Demonstrated record of leveraging in vivo pharmacology models to explore cancer biology and enable cancer drug discovery. – Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and GEM models. – Skilled and proficient at independently running xenograft mouse studies to perform model development, anti-tumor efficacy, PK/PD and combination studies in conjunction with necropsy/tissue/blood collection across multiple projects with delivery of high-quality data. – Proficiency in cell culture, passaging and harvesting cells is required. Skilled at murine dosing via PO, IP, IV, SC routes. – Experience with multi-parameter flow cytometry to investigate immune function of tumor infiltrating lymphocytes is desired – Demonstrated experience executing ex vivo assays to investigate target engagement, mechanism of action and biomarkers by qPCR, ELISA (MSD), WB. – Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required. – Attention to detail with excellent organizational and record keeping skills is a requirement. Ability to work collaboratively across departments, understand and implement applicable regulations around animal care/safety/handling desired. – Strong written and verbal communication skills with the ability to interact effectively with peers and management. Capable of presenting scientific results to multidisciplinary teams and key stakeholders. – Highly motivated and ability to be flexible in case of changing priorities. Ability to mentor junior associates and colleagues on best practices in the laboratory. – This position is located in Cambridge, MA. Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.