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Neuroscience Post Doctoral Research Fellow

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Company :
Mass General Physicians Organization(MGPO)

Location :
Boston, Massachusetts

Expiry Date :
Mon, 08 Mar 2021 23:59:59 GMT

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Description :
Employer Name: SpiderID: Location: Boston, Massachusetts Date Posted: 2/4/2021 Wage: Negotiable Category: Law Enforcement/Security/Safety Job Code: -1492 Job Description: The Perlis Laboratory in the Center for Quantitative Health (CQH),part of the Center for Genomic Medicine (CGM) at the Massachusetts GeneralHospital and Harvard Medical School is seeking highly motivated post-doctoralfellow candidates. Immediately available position is ideal for thoseexperienced in neurobiology, stem cell biology, neural disease modeling, large-scaleomics studies and developmental genetics. The new hire will be appointed as a Research Fellow at theMassachusetts General Hospital and Post-Doc at the Harvard Medical School. Thisis a fully supported appointment with annual renewal based on merit andachievement. The fellow will also be expected to apply for competitive fundingopportunities as available. PRINCIPAL DUTIES AND RESPONSIBILITIES: The Post-doctoral Fellow principal duties and responsibilities willinclude performing cutting edge research in the following areas: human inducedpluripotent stem cell (iPSCs) and neural stem cell models of neural disease,neuroimmunology (e.g. microglia), cellular differentiation and sequencing(RNAseq, scRNAseq, Plate-seq, CRISPr screens, etc.) to identify and understandthe mechanisms of action of novel targets and putative therapeutics for thetreatment of neuropsychiatric disorders. This position will involve coordinationand mentoring of junior technical staff, participate in laboratory managementand research planning while working independently on high-priority projects. The Post-Doctoral fellow will be situated in the MGH under theguidance and mentorship of Dr. Roy. H. Perlis MD, MSc (PI) and Dr. Steven D.Sheridan, Ph.D. SKILLS & COMPETENCIES REQUIRED: The ideal candidate should have received (or expect to receivesoon) a Ph.D. in neurobiology (including neurodevelopment, neuroinflammation,neurodegeneration, etc.) or a related field. – Experience in deriving and utilizing neural cultures for cellular modeling of disease (e.g. neuronal culture, iPSCs, organoids, neural stem cells, microglia, astrocytes, etc) – Experience with commonly used bioinformatics tools and databases (e.g. demonstrated competence in languages such as R or Python for bioinformatics analyses). – High-content image analysis experience a plus. – First (or co-first) author of one or more peer-reviewed scientific publications. – Excellent English verbal and written communication skills. – Able to work both independently and within a collaborative team environment. EDUCATION and EXPERIENCE: Candidates should hold a PhD with preference given to applicantswith a strong interest in and research training relevant to the areas of neuraldevelopment, microglial function, neuroinflammation, human cellular models ofneurological disease, transcriptional regulation including sequencing and orCRISPr screens. In addition to demonstrated experience in the culturing andmaintenance of in vitro humancellular models systems, a strong background in working with high dimensionaldata (e.g. high-throughout gene expression analyses, single cell sequencing, CRISPrscreens, proteomics data, etc.) is highly preferred. WORKING CONDITIONS: The fellow will be situated in the CGM allowing collaboration withother neuroscientists, stem cell biologists, clinicians and computationalbiology and genomics investigators; and will also have full access to themolecular biology / biochemistry / cell culture and computational resources inthe Perlis Lab. Interested applicants should submit their CV and contacts forreferences to: Steven D. Sheridan, Ph.D. () EEO Statement Massachusetts General Hospital is an Equal OpportunityEmployer. By embracing diverse skills, perspectives and ideas, wechoose to lead. Applications from protected veterans and individuals withdisabilities are strongly encouraged. Qualifications EDUCATION and EXPERIENCE: Candidates should hold a PhD with preference given to applicants with a strong interest in and research training relevant to the areas of neural development, microglial function, neuroinflammation, human cellular models of neurological disease, transcriptional regulation including sequencing and or CRISPr screens. In addition to demonstrated experience in the culturing and maintenance of in vitro human cellular models systems, a strong background in working with high dimensional data (e.g. high-throughout gene expression analyses, single cell sequencing, CRISPr screens, proteomics data, etc.) is highly preferre EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. Partner’s Healthcare is acting as an Employment Agency in relation to this vacancy. Job Criteria: Start Date: Position Type: Full-Time Permanent Years of Experience Required: Education Required: Overnight Travel: Vacation Time: Contact Information: Contact Name: Partner’s Healthcare Company Type: Company: Mass General Physicians Organization(MGPO) City: State: Zip: