Principal Scientist, CAR/TCR Biology

  • Anywhere

Company :
Bristol-Myers Squibb

Location :
Seattle, Washington

Expiry Date :
Sun, 06 Dec 2020 23:59:59 GMT

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Description :
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. The Preclinical CAR T and TCR Biology team is seeking an experienced and driven immunologist with a strong background in T cell biology to advance anti-tumor cell therapies by leading efforts for optimization of CAR T and TCR engineered therapeutics. The successful candidate will have experience in tumor-associated T cell immunology, supervisory experience and a passion for T cell therapy research. Working in lead optimization of T cell therapeutics, this position is ideal for the scientist who is interested in continually learning new technologies to incorporate into CAR/TCR engineered T cell therapeutics in a fast-paced, collaborative and innovative environment. Responsibilities include but are not limited to: – Application of extensive knowledge of T cell biology including activation pathways, signaling pathways and antigen-specific driven differentiation to optimization of lead CAR/eTCR T cell therapeutic candidates – Designing and implementing critical studies required to drive hypothesis-driven research – Conceive and develop novel in vitro assays/models to evaluate CAR T/TCR engineered T cell functionality – Identify and present opportunities to develop scientists – Mentoring direct reports to provide guidance for outlining studies required for project advancement – Provide leadership and shape the culture of a functional group – Anticipates the need for contingencies and demonstrates flexibility through development of alternative strategies – Identification and conception of novel strategies for improving T cell function and leading design and characterization activities to enable science-driven decision making – Building constructive relationships across the organization to achieve the goals of the function and the business through leadership roles on cross-functional/divisional teams Qualifications: – Ph.D. in immunology, immune-oncology or tumor immunology with at least 3 years of successful postdoctoral experience as demonstrated by strong publication record plus at least 5 years of experience in an industry setting or a M.S. with a minimum of 14 years of relevant work experience or B.S. with minimum of 16 years of relevant work experience in T cell immunology – Experience with technologies typically employed to assess T cell functionality including but not limited to MSD, IncuCyte-based assays, multi-parameter flow cytometry for phenotypic characterization of T cells, T cell activation assays, T cell proliferation analysis, imaging technologies – Demonstrates in-depth, scientific-directed, innovative thinking – Self-motivated and focused with project management-oriented thinking; able to work on multiple projects in a matrix environment – Ability to work well as both team member and as individual contributor is essential – Good communication skills for cross-functional interactions as well as upper management interactions; excellent oral presentation skills are critical – Requires strong organizational skills to ensure thorough and timely documentation of experiments, including those of their direct reports, and preparation of data for compiling reports – Experience leading projects through building/leading cross-functional teams – Supervisory experience is required BMSCART Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.