Principal Scientist, Immune Oncology and Cellular Therapy Translational Development

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Company :
Bristol-Myers Squibb

Location :
Seattle, Washington

Expiry Date :
Sun, 06 Dec 2020 23:59:59 GMT

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Description :
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Principal Scientist, Immune Oncology & Cellular Therapy Translational Sciences We are looking for a talented principle scientist to be part of the translational research group based in Seattle. Responsibilities of this role are to act as the global project team translational lead for a key cellular therapy asset, mentor junior translational scientists, to align translational strategy and research for their program across indications and studies, and review and apply translational learnings within the group and cross-functionally by engagement of key stakeholders. Expertise in developing and qualifying biomarkers for clinical trials, and strong knowledge in immunology and tumor biology is required. Responsibilities: – In-depth knowledge of fundamentals of immunology, immune oncology, and/or tumor biology in hematological malignancies – Utilization of translational based approaches to develop new concepts and mechanism of action hypotheses, and identifying distinguishing pharmacodynamic characteristics of compounds alone and in combination with other therapies – Knowledge of biomarker discovery and development: assay development/validation, clinical discovery of biomarkers, MoA research, knowledge of platforms – Experience and knowledge of CART therapies and translational challenges – Design and execution of primary immune cell-based assays – Supervise scientific and technical staff – Manage internal projects in immune oncology drug development – Serve on internal project teams and committees as scientific functional lead – Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics. – Understand the context, impact and timely communication of data Specific Duties: – Implementin-vitroimmunologic assays for evaluating activity and mechanism of action of immune oncology drug candidates using primary cell cultures and patient samples – Developin-vitroandex-vivoassays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials – Critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps – Supervise Scientists and Associate Scientific staff – Participate in team meetings to present data and provide interpretation – Establish and maintain working relationship with contract laboratories and relevant academic collaborators – Ensure that the group maintains current awareness in area of expertise, enhance the scientific credibility of Bristol-Myers Squibb through contributions to the scientific literature (publications/presentations) – Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate Qualifications: – Ph.D. degree in immunology, tumor biology or cellular biology, or pharmacology with at least 3 years of successful post-doctoral experience, evidenced by a strong publication record, plus a minimum of 10 years of successful experience as a scientist in the biotechnology or pharmaceutical industry setting – Excellent communication and interpersonal skills demonstrated in a team environment – Expertise in developing biomarkers for clinical trials, and strong knowledge in immunology and tumor biology, knowledge of hematopoietic malignancies desired – Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology (molecular cloning, transient and stable gene silencing, methylation specific PCR) – Familiarity with data management tools and software for analyzing translational data sets from various assay formats. Biological interpretation of high content data sets in collaboration with computational biology – Effective team building and teamwork skills and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors BMSCART Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.