Principal Scientist Scientist Discovery Attribute Sciences

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Thousand Oaks, California

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Fri, 26 Mar 2021 23:59:59 GMT

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Job Details Full-time2 hours ago Qualifications – Microsoft Excel – Microsoft Office – Analytical chemistry – Spectrometer – Research – Doctoral degree Full Job Description Career Category Research Job Description HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our d missionto serve patientsdrives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Join us. Principal Scientist – Discovery Attribute Sciences Live What you will do Let’s do this. Let’s change the world. In this vital role you will be a aprt of the Discovery Attribute Sciences group providing scientific and technical expertise to support early discovery research through to later stage molecule optimization and late-stage selection of Amgen’s pipeline of drug candidates. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. Identifying and characterizing attributes of therapeutic protein candidates utilizing multiple analytical techniques. Develop and novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on mass spectrometry (LC-MS, LC-MS/MS and MALDI-MS), capillary electrophoresis (and CE-MS), cation exchange (and CEX-MS), size exclusion chromatography (and SEC-MS) and other biophysical techniques such as calorimetry and rheology. Experience with LC-MS/MS to map and characterize post translational modifications such as deamidation, isomerization and oxidation would be advantageous. Investigation, development and the application of miniaturized and high throughput mass spectrometric methods is expected. This role will also involve supervising and mentoring a small group of MS-focused scientists. Importantly, the expectation for this role is also to be 75% laboratory based, providing support for multiple projects and their advancement and also be able to perform innovative MS application and method development. Experience with small molecule MS and MS/MS accurate mass measurements, empirical formulae derivation and structural characterizations would be advantageous. Communicate (verbal and in written) scientific concepts and results. Work collaboratively with other scientists on multidisciplinary teams. Work independently in advancing projects and studies within required deadlines. Actively create or contribute to patent and publications. Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen. Demonstrate external scientific eminence in the form of peer-reviewed publications and conference presentations. Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in d Win What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is a proven leader with these qualifications. Basic Qualification A doctorate degree with 7-10+ years in Analytical Chemistry, Biochemistry or equivalent with emphasis in mass spectrometry and other analytical characterization techniques, such as reversed-phase, size exclusion chromatography, capillary electrophoresis. Relevant experience working as part of a multidisciplinary team in a biopharmaceutical setting would also be an advantage. Preferred Qualifications Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantitation of chemical modifications, native mass spectrometry, ion mobility and experience with different fragmentation techniques such as ETD, ECD and HCD. Training and experience of operating Thermo Orbitrap, Agilent and Waters Q-ToF mass spectrometers, Waters and Agilent UPLCs would be advantageous. Proficiency with Microsoft Office. Knowledge of statistical processing of data, including related software like Excel, Spotfire, JMP or ArrayStudio and multiple mass spectrometric 9MassLynx, MassHunter, XCalibur) and chromatographic software (ChemStation) control and data processing (MaxEnt, PMI Intact) packages is required. Thrive What you can expect of us As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being. Vast opportunities to learn and move up and across our global organization Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits now for a career that defies imagination In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us. Equal Opportunity Statement Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation. . Show full job description Apply Now