Research Associate

  • Anywhere

Company :
Skyhawk Therapeutics

Location :
Waltham, Massachusetts

Expiry Date :
Tue, 15 Dec 2020 23:59:59 GMT

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Description :
Skyhawk Therapeutics is seeking a highly motivated Research_Associate to join our talented, growing team in Waltham, MA. The successful candidate will be part of an interdisciplinary research team, working at the interface of molecular biology, biophysical, and biochemical methods. Skyhawk is committed to discovering, developing, and commercializing small molecule therapeutics that correct RNA splicing. We use our novel SkySTARTM platform (Skyhawk Small molecule Therapeutics for Alternative splicing of RNA) to develop drug candidates directed to targets for some of the world s most intractable diseases including cancer, neurological conditions, and other undruggable targets against a wide range of conditions. Position_Overview The research associate will perform molecular biology and cell biology techniques, including (but not limited to) DNA/RNA isolation, DNA/RNA QC, RT- qPCR, sequencing library preparation, cell culture, and in vitro drug screens. The ideal candidate will have industry experience and previous exposure to experimentation/analysis methods involving RNA. Other responsibilities include regular maintenance of equipment, tracking sample kit inventory, and participating in regular laboratory meetings. Role_and_Responsibilities_(include,_but_are_not_limited_to): * Design and conduct molecular & cellular biology experiments for compound screening or mechanism in cell lines or engineered mammalian cell lines. * Perform basic cell biology techniques including mammalian cell cultures, transfection and drug treatments. * Design and execute qPCR and RT-PCR for gene expression and splice variants, respectively. * Perform basic molecular biology and biochemistry techniques including RNA/DNA extraction, and western blot analyses. * Work closely with senior/principal scientist to design, develop and execute experiments. * Help maintain equipment and assist in ordering laboratory supplies. * Record experiments accurately in a timely manner and summarize/report data. * Clearly and efficiently communicate with multidisciplinary teams to integrate activities with programs. * Participate in project lab, team or company meetings, and scientific discussions. * Ensure that all safety guidelines are strictly followed at all times and maintain a clean and orderly work environment. * Summarize obtained data in an organized and presentable fashion. Education/Skills/Experience_Requirements: * B.A., ., or M.S. with 2+ years laboratory experience * Hands-on experience with RNA biology, including functional analyses of RNA binding protein/small molecule-RNA complexes, mammalian cell culture, and site-directed mutagenesis * Proven experience in working independently as well as in a team environment * Proficiency in MS Office package and GraphPad prism * Excellent written and oral communication skills * Flexible and efficient with a problem-solving attitude in a fast-paced small company environment To Apply: Please send resume and cover letter to A_COVER_LETTER_IS_REQUIRED. Please explain why this job is of interest to you. Detail your strengths and weaknesses as they pertain to the requirements and responsibilities of this position. Show moreShow less