Research Associate, Assay Development
Expiry Date :
Mon, 14 Jun 2021 23:59:59 GMT
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POSITION SUMMARY: This position is in the Biotechnology and Advanced Chemistry Technology groups and is primarily a bench level job focusing on real time PCR and RT-PCR assay and product development in an FDA-QSR and ISO9001 compliant organization. The successful candidate will initiate, direct and execute pre-clinical scientific research and/or development strategies in research and/or development with particular focus on real time PCR assay design, development and verification. The ideal candidate will investigate the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems and is expected to have a proven track-record of helping to launch in vitro diagnostic products. The candidate will plan and execute laboratory research, demonstrate appropriate technical proficiency, scientific creativity, collaboration with others and independent thought while developing PCR assays for detection of bacteria, viruses, and for tracking host biomarkers. The candidate will be expected to interface with various internal departments as well as external agencies and collaborators. ESSENTIAL JOB RESPONSIBILITIES: * Design and develop real time PCR and RT-PCR assays for the GeneXpert platform for detection of bacteria and viruses or towards tracking of host biomarkers. * Optimize reagent and assay bead formulation for assays in the GeneXpert platform. * Perform rigorous analytical studies required for technical feasibility and design verification phases of complex assays prior to validation phase. * Handle samples and perform microbiology work of BSL-1 and BSL-2 organisms, including BSL-2 strains. * Help develop strategies for development of complex in vitro diagnostic tests. * Help develop and write verification and validation SOPs and technical reports. * Maintain detailed experimental records. * Apply analytical problem solving skills to reagent and system integration issues to identify critical performance factors. * Present data at technical meetings. * Allocate time and resources efficiently, effectively prioritize, and continually seek ways to improve individual and corporate efficiency. MINIMUM REQUIREMENTS: Education and Experience: * Bachelor’s degree with 2+ years of related work experience or * MS with 0-1 year of experience. Knowledge and skills: * Experience interfacing with chemistry teams and chemical technology development projects a plus. * Some knowledge of molecular biology techniques to proactively troubleshoot assays, to resolve technical issues and challenges, and to perform data interpretation is desirable. * Strong organization and problem-solving skills and proven ability to manage details. * Comfortable working in a BSL2 environment and with a variety of clinical sample matrices. * Some skills in experimental design, implementation, troubleshooting, and data analysis. Physical requirements/abilities: * Must be able to perform routine laboratory tasks. * Work may involve repetitive arm/wrist motions. Other: * Some travel is expected including to our Sunnyvale, CA, locations as well as external collaborators as needed. PREFERRED REQUIREMENTS: * Hands-on experience in optimization of formulations that impart stability and robustness of new technologies targeted for fast nucleic acid amplification (isothermal, PCR/RT-PCR) reagents. * Working knowledge of DOE-based assay optimization is a plus. * Proficiency with one or more common statistical/graphical analysis software(s) (JMP, MiniTab) is ideal. * Working knowledge of method validations and method transfers. Danaher Corporation and all Danaher Companies are equal opportunity employers that evaluate qualified applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law. The EEO is the Law poster is available here.