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Research Associate CA

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Company :
Advent Global Solutions

Location :
San Diego, California

Expiry Date :
Sun, 06 Dec 2020 23:59:59 GMT

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Description :
Position Research Associate (1-year contractor) Prerequisite Bachelor’s degree in a scientific discipline with at least 3 years work experience or Master’s degree with at least 2 years work experience. Description Client is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to Client and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries – and growing we look for talented people to grow our business, advance our science and contribute to our unique culture. The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of Client paradigm-changing therapeutics. Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE), including Protein Homeostasis, Epigenetics, Immuno-oncology and Inflammation & Immunology. Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team. Summary/Scope The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of Client cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership. Responsibilities will include, but are not limited to, the following: – Optimize and perform next generation sequencing libraries to define MOA of candidate agents – Genetic manipulation in cancer cell lines using CRISPR-Cas9 technology – Generate stable cancer cell lines via retroviral or lentiviral transduction – Conduct flow cytometry-based assays – Conduct routine cell based assays to characterize drug candidates – Design research protocols in collaboration with the principal investigator – Plan and execute scientific experiments related to one or more programs independently – Convey data analysis and interpretation to supervisor and colleagues – Communicate with peers and supervisors and foster teamwork – Contribute to collaborative efforts – Strong commitment to quality and reproducibility – Demonstrate adaptability Skills/Knowledge Required – Extensive experience working with RNA and generating next generation sequencing libraries – Extensive wet-lab experience with molecular and cell biology including molecular cloning, western blot, immunoprecipitation, flow cytometry, realtime-qPCR, ELISA, lentivirus preparation and infection, etc. – Extensive experience with Cas9-CRISPR mediated gene editing and RNAi – Highly motivated and strong team player with a high degree of independence – Innovative and critical thinking – Excellent time management and organizational skills – Strong communication skills, both written and oral