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Research Associate I / II, QC Analyst

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Company :
Tenaya Therapeutics, Inc.

Location :
South San Francisco, California

Expiry Date :
Mon, 21 Jun 2021 23:59:59 GMT

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Description :
Tenaya Therapeutics is a preclinical-stage, Series C, privately-held biopharmaceutical company that is shaping the future of heart disease treatment driven by a bold mission: to discover, develop and deliver curative therapies that address the underlying drivers of disease. Tenaya is developing therapies for rare genetic disorders as well as for more prevalent heart conditions through three platforms: Gene Therapy, Regeneration and Precision Medicine. Founded by leading cardiology researchers at the Gladstone Institutes and UT Southwestern, Tenaya is backed by a top-tier syndicate of investors, including The Column Group, Casdin Capital, RA Capital, RTW, Fidelity, T Rowe Price, GV and others. Tenaya Therapeutics currently has 75+ full-time employees (not including consultants) and is headquartered in South San Francisco, California, USA. For more information, please visit [ and follow us on LinkedIn.
Tenaya encourages those from under-represented communities to apply.

Role

Tenaya has an immediate need for a Research Associate to support the Technical Operations Analytical Development/Quality Control Group. The ideal candidate is a self-starter and problem-solver who will work closely with the team to drive the companys future success. Ideally, you thrive in a startup, fast-paced environment where every day is unique. You are confident, poised and cool-headed, no matter how much is changing around you. You have a strong eye for detail and strive for excellence in every facet of your work and you understand the excitement and commitment of start-up roles. Finally, you love being part of a team aligned around a compelling mission.

In this role, you will perform key molecular biology and cell based assays to support Process Development and manufacturing activities; troubleshoot assays as needed; assist with the development and refinement of analytical methods to determine the strength, purity and/or potency of viral vector preparations. Other activities include SOP writing, lab maintenance, and supply ordering.

Key Responsibilities

Perform quality control release assays in support of Process Development activities (e.g. viral

genome titer, capsid titer, cell-based assays, residual impurity characterization).

Follow written procedures and SOPs. Optimize and modify procedures, as necessary.

Maintain excellent written documentation (e.g. lab notebook and test forms).

Maintain necessary supplies and equipment, prepare reagents, and train team members.

Contribute to routine laboratory and instrument maintenance.

Troubleshoot, optimize, and trend assay performance.

Transfer assays and perform assay qualification, write transfer/qualification reports under direction of supervisor.

Requirements

Bachelors or Masters degree in Biology, Biochemistry, or related discipline with 0-2 years of

experience in research, analytical and/or quality control.

AAV, gene therapy, and viral vector experience is a plus.

Prior experience in quality control, manufacturing, or healthcare, or other regulated industry is a plus.

Experience with mammalian cell culture and aseptic techniques.

Familiarity with one or more of the following: qPCR, ddPCR, capsid titer, cell-based transgene potency, residual impurity characterization, flow cytometry, ELISA or other immunochemical assay.

Significant attention to detail in writing, reviewing and following written procedures. Strong ability to identify inconsistencies in written procedures and address them independently.

Excellent interpersonal, communication and organizational skills.

Ability to be highly productive in a fluid, fast-paced and teamwork-oriented environment.

Benefits

We offer a dynamic start-up environment and a collaborative, passionate team that is focused on a compelling vision and mission.

We offer competitive salary and stock options. Excellent medical and non-medical benefits. Paid vacation, sick time and holidays.

State-of-the-art, built-to-suit office and lab space, part of a larger cluster of biotech companies, with amenities that include a bowling alley and onsite gym.

Shuttle service to/from Caltrain, BART and the South San Francisco Ferry.

Tenaya is proud to be an equal opportunity workplace.