Research Associate II, Bioassay Development

  • Anywhere

Company :
Tenaya Therapeutics, Inc.

Location :
South San Francisco, California

Expiry Date :
Tue, 20 Jul 2021 23:59:59 GMT

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Description :
Tenaya Therapeutics is a preclinical-stage, Series C, privately-held biopharmaceutical company that is shaping the future of heart disease treatment driven by a bold mission: to discover, develop and deliver curative therapies that address the underlying drivers of disease. Tenaya is developing therapies for rare genetic disorders as well as for more prevalent heart conditions through three platforms: Gene Therapy, Regeneration and Precision Medicine. Founded by leading cardiology researchers at the Gladstone Institutes and UT Southwestern, Tenaya is backed by a top-tier syndicate of investors, including The Column Group, Casdin Capital, RA Capital, RTW, Fidelity, T Rowe Price, GV and others. Tenaya Therapeutics currently has 75+ full-time employees (not including consultants) and is headquartered in South San Francisco, California, USA. For more information, please visit [ and follow us on LinkedIn [

Tenaya encourages those from under-represented communities to apply.


Tenaya is a growing biopharmaceutical company with a goal to create a new generation of therapies for the treatment of heart disease. We are progressing our reprogramming gene therapy project towards a development candidate and IND filing. We are establishing target and drug discovery technologies including the development of a panel of iPSC-CMs representing human disease-causing mutations. Our mission is to become a preeminent biopharmaceutical company discovering and developing medicines to cure heart failure.

We are seeking a motivated, knowledgeable Research Associate with a positive attitude to join our Analytical Development team and focus on the development of relevant in vitro potency assays for gene therapy viral vectors. This position will be responsible for the development, qualification and transfer of cell-based potency and mechanism-of-action bioassays for Tenayas clinical pipeline. You will be part of a dynamic small company environment dedicated to finding new, cutting-edge therapies for heart disease.
Description of the Position
Assist in the development and optimization of cell-based assays for the in vitro potency/mechanism of action of gene therapy viral vectors, with input from your supervisor. Assays may include viral vector infectivity; transgene mRNA expression; transgene protein expression; transgene protein activity; and/or cellular morphology assessment.

Qualification of these cell-based assays for release testing and assist with transfer of the methods to internal Quality Control or external contract testing laboratories. Assist testing labs in troubleshooting the methods as appropriate.

Performance of these assays on process and/or product related samples in support of process development & optimization, characterization, release testing, scale-up and comparability studies.

* Learn and implement laboratory techniques and demonstrate excellent levels of accuracy and quality.


* Sunday Thursday


Familiarity and experience in mammalian cell culture.

Excellent aseptic techniques.

Knowledge of general cellular and molecular biology laboratory techniques.

Ability to trouble-shoot analytical methods and equipment

The ability to work in a fast-paced team environment and to meet challenging deadlines under pressure.

Team-oriented (cooperative and collaborative), having a positive and Can-Do attitude. Able to work with a variety of team members.

* Education: Bachelors or Masters degree in a Biological Science or Biotechnology-related subject (or equivalent). Physical science degrees also considered, with relevant experience.

Familiarity with cellular mRNA or protein expression assays, or viral infectivity assays.

Good understanding of bioprocess development and the manufacture of biopharmaceuticals would be advantageous.

Experience with a range of applicable analytical techniques, e.g., cell-based and /or flow cytometry-based assays, nucleic acid extractions, DNA sequencing, qPCR/ddPCR, SDS PAGE, Western blot analysis, ELISA, HPLC/UPLC, etc.

Experience with testing or production of AAV vectors is highly preferred.

* Experience designing, executing, analyzing, and summarizing experiments for assay verification, qualification and validation reports is preferred.
* Experience with ELN (electronic lab notebook).


We offer a dynamic start-up environment and a collaborative, passionate team that is focused on a compelling vision and mission.

We offer competitive salary and stock options. Excellent medical and non-medical benefits. Paid vacation, sick time and holidays.

State-of-the-art, built-to-suit office and lab space, part of a larger cluster of biotech companies, with amenities that include a bowling alley and onsite gym.

Shuttle service to/from Caltrain, BART and the South San Francisco Ferry.

Tenaya is proud to be an equal opportunity workplace.