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Research Scientist, Immuno Oncology Discovery

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Company :
Johnson & Johnson Family of Companies

Location :
Spring House, Pennsylvania

Expiry Date :
Sun, 28 Mar 2021 23:59:59 GMT

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Description :
Job Details Full-timeEstimated: $81,000 – $110,000 a year3 hours ago Qualifications – Flow cytometry – Communication skills – Molecular biology – Bachelor’s degree – Doctoral degree – Master’s degree Full Job Description Janssen Pharmaceutical Research & Development, L.L.C. is currently recruiting for a Research Scientist-Immuno Oncology Discovery, to be located in Springhouse, PA. At the Janssen Pharmaceutical companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. and we pursue the most promising science, wherever it might be found. Janssen Research & Development, discovers and develops innovative medical solutions to ress important unmet medical needs in Oncology, Immunology, Neuroscience, Infectious diseases and Vaccines, and Cardiovascular and Metabolic diseases. Please visit for more information. We are Janssen, our mission drives us, our patients inspire us, we collaborate with the world for the health of everyone in it. Primary Responsibilities of the Research Scientist position include: Lead and Support the identification, validation, and drug development efforts to deliver novel immuno-oncology therapeutics for the treatment of Oncology indications Support the identification, development, and implementation of biomarker strategies for oncology immuno-modulatory compounds and combinations in stages from discovery to early and mid- clinical development Design, perform and interpret complex in vitro, ex vivo, and in vivo experiments to investigate immune cell function in cancer with the aim of advancing the Oncology pipeline. Communicate scientific results to multidisciplinary teams, project leader, and to senior management. Design, execute, and interpret studies for the identification, validation, and characterization of immunogenicity assays with proliferation and cytokine endpoint readouts for the characterization of immune responses to both neo and self-antigens Design, execute, and interpret complex in vitro, ex vivo, and in vivo experiments to evaluate mechanism of action associated with immune cell function with the aim of advancing the Oncology pipeline Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements Culture multiple primary cell types and cancer cell line simultaneously under aseptic conditions Establish robust assay readout metrics (e.g. EC50/IC50, max response, response above background) for the comparison and ranking of experimental agents Process human or mouse tissue (blood, lymph nodes, tumor, prostate, lung, muscle, spleen, and thymus) to single cell suspension for analysis of immune cell and stromal cells by Flow cytometry Stain and characterize immune cell population by multiparameter (8-16 colors) flow cytometry (e.g. Fortessa, Canto, Celesta) Qualifications A PhD degree in Pharmacology, Immunology or tumor immunology related field, with 2+ years post-doctoral experience working in tumor immunology or related field with a demonstrable record of scientific achievement is required. Alternatively, a BS or MS degree with at least 7+ years of relevant pharmaceutical experience in the areas of immunology or oncology may be considered. Experience with multiparameter flow cytometry (8-16 color; Fortessa, Canto, Celesta) of immune cell populations and analysis using FlowJo software is required. Expertise in design and interpretation of immunogenicity assays/experiments to evaluate antigen-specific T cell reactivity including Spotfire analysis software is required (Elispot, ICS, ELISA, MSD) A proven track recording a variety of Cellular and Immunology based techniques to isolate, phenotype and functionally test peripheral and tumor infiltrating lymphocytes is required. Expertise in molecular biology including RNA, DNA and protein analysis is preferred. Experience with vaccines and oncolytic virus immunology/Immuno-oncology is preferred. Experience with in vivo models of tumor biology is preferred. Ability to supervise and guide junior scientists is preferred. Detail-oriented, with excellent record-keeping skills is required. Excellent communication and collaborative skills are essential including; interfacing with group leaders to ensure that in vitro and in vivo testing requirements and time lines are met; developing and presenting summaries of data, writing clear and succinct study reports; and effective interfacing with other cross functional groups. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Eradicate cancer Primary Location United States-Pennsylvania-Spring House-Welsh & McKean Roads Organization Janssen Research & Development, LLC (6084) Job Function R & D Requisition ID W Show full job description Apply Now