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Scientist I, Nucleic Acid Delivery, Drug Delivery and Nanoparticle Research

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Company :
Ultragenyx Pharmaceutical

Location :
Novato, California

Expiry Date :
Mon, 16 Nov 2020 23:59:59 GMT

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Description :
Job Details

Full-timeEstimated: $73,000 – $97,000 a year2 hours ago

Qualifications

– Time management
– Laboratory experience
– Organizational skills
– APIs
– Research
– Bachelor’s degree
– Doctoral degree

Full Job Description

Why Join Us?
Be a hero for our rare disease patients

Ultragenyx is a commercial-stage biopharmaceutical company committed to developing novel therapies for the treatment of rare and ultra-rare genetic diseases. The company has rapidly built a diverse portfolio of small molecule, monoclonal antibody, mRNA and gene therapy candidates with the potential to ress debilitating genetic diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are typically no approved therapies treating the underlying disease.

Developing new treatments for rare genetic diseases is challenging work. It takes courage, talent, and dedication to look past the easy answers and uncover new solutions that can make a meaningful impact. At Ultragenyx we push each other to perform at our very best, because we never lose sight of our mission – to make a difference in our patients’ lives.

Come join our team during this exciting time of growth and opportunities! During the COVID-19 Outbreak we are committed to our hiring process. The health and safety of our employees and prospective employees take priority which means at this time our process will include WebEx video discussions, interviews & onboarding.

Position Summary
ultrainnovative – Tackle rare and dynamic challenges

We are seeking a highly motivated, dynamic Scientist to join the Research department with experience in the development, optimization and production of preclinical formulations to support the nucleic acid platform and preclinical research programs in the area of rare diseases. The candidate will work with internal members and collaborators to optimize nucleic acid lipid nanoparticle (LNP) formulations for in-vitro and in-vivo studies. The Scientist will be responsible to rapidly identify and produce appropriate LNP formulations; establish and carryout the supporting analyses to ensure the characterization of the formulated test articles; and inform final formulation selection and transfer to our development team. Responsibilities include independent planning and execution of experimental work, data analysis and presentation of material at project team meetings. The candidate is expected to collaborate and work dynamically on diverse projects/platforms, communicate effectively on scientific concepts and interact with colleagues in other functional areas. Cross-functional collaboration with Technical Operations may be required for technology transfer of novel LNP formulations.

Responsibilities including, but not limited to:
Produce high quality and well characterized Nucleic Acid Lipid NanoParticle (LNP) formulations to support Nucleic Acid Platform activities and project-related studies
Perform optimization of LNP formulations to improve drug properties, including solubility, stability, sustained release, bio-distribution, and efficacy
Perform comprehensive operating range studies to understand formulation/process limits, as well as formulation stability studies
Perform process related investigations, identify root causes of process discrepancies, and implementing appropriate steps to ensure process robustness
Design and execute laboratory experiments to confirm feasibility of processes and techniques used in the production of materials having special characteristics.
Conduct research on the properties of materials and polymers to obtain information that will be used to develop new products or enhance existing ones.
Coordinate and conduct pre- and post-study dose formulation analyses.
Partner with stakeholders to ensure premix compatibility with their end-product (product processing conditions, shelf-life requirements, application)
Collaborate with internal team members, external collaborators, and CROs to execute experiments to support platform projects and to provide technical expertise
May determine methods to strengthen or combine materials or develop new materials with novel or specific properties for use in a variety of products and applications.
May recommend materials for reliable performance in various environments.
May visit or communicate with suppliers of materials or users of products to gather specific information.
Execute and troubleshoot standard protocols, develop and adapt new protocols into practice and query literature to incorporate itional assays as needed.
Generate thorough production batch records and tech transfer information for further product development when needed
Communicate effectively by providing regular verbal and formal updates to manager, project team leaders and senior leaders.

Requirements:
Degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, bioengineering or other industry-relevant fields. PhD with 2+ years of related experience, MS with 6+ years of related experience or BS/BA with 8+ years of related experience.
Post-graduation hands-on laboratory experience developing LNP formulations in academic and/or industrial setting is required.
Strong hands-on experience with the formulation development process of Lipid NanoParticles (LNP) encapsulating nucleic acids (mRNA, siRNA, ASOs).
Experience in LNP formulation optimization to improve drug like properties; solubility, increase stability, mitigation of API aggregation, active targeting using ligands or aptamers.
Experience in bio/analytical and biophysical methods used for characterization of LNP formulations and implementation of the technologies required for formulation optimization.
Experience with Precision NanoSystems instrumentation is a plus.
Knowledge of the nucleic acid manufacturing process is a plus.
Knowledge of mass spectrometry techniques for bioanalysis of nucleic acids is a plus
Excellent data recording and ensuring high quality, timely documentation in laboratory notebook.
This position requires excellent organizational skills, agility and time management in order to meet deadlines in a fast-paced organization
Demonstrated independence at the bench and ability to work collaboratively on projects.
Ultragenyx Pharmaceutical is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status. Reasonable accommodation will be provided for qualified individuals with disabilities and for qualified disabled veterans in job application procedures, as required by applicable law. If you have any difficulty using our online application system and need an accommodation due to a disability, you may contact Talent Acquisition by calling: or by emailing us at . For electronic email and mail inquiries, please include a description of your requested accommodation, your name and contact information.

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