Scientist (Nonclinical Safety

  • Anywhere

Company :
Bristol-Myers Squibb

Location :
Seattle, Washington

Expiry Date :
Tue, 06 Apr 2021 23:59:59 GMT

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Description :
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Bristol Myers Squibb (BMS) is developing clinical-stage, novel cellular immunotherapies based on two distinct and complementary modalities- Chimeric Antigen Receptor (CAR) and T Cell Receptor (TCR) technologies. Cell therapy is one of the most groundbreaking new forms of cancer treatments and our goal is to deliver innovative cell-based therapies to patients. We hire the best people and provide them with a work environment that strives for diversity, collaboration, innovation and personal development. The Drug Safety Evaluation Cell Therapy team, which is part of the Nonclinical Development (NCD) group, is seeking an innovative research scientist to evaluate the fundamental biological components associated with potential toxicities of CAR-T- and TCR-T cell therapies. The scientist will serve as an integral member of the team that supports all cell therapy programs at BMS. The team is responsible for establishing the preclinical safety strategy for new CAR and TCR targets, genomically-edited cells and armored cell products. Safety studies for cell therapies is an evolving field that requires creative and talented individuals to shape the field for novel and more sophisticated cell therapies. The candidate for this role requires the ability to help identify potential clinical or scientific risks with CAR-T and TCR-T cell products, to develop and implement in vitro platforms and technologies that will allow testing and understanding the biology that impacts safety, and to communicate results to NCD as well as global project teams. A successful candidate requires robust knowledge in cellular and molecular immunology, and expertise in developing in vitro model systems. Primary Responsibilities Include: – Ability to understand mechanistic aspects of adoptive cell therapy, CAR and TCR specificity and to identify biologic aspects that may represent safety risks – Design and conduct experiments to predict on- and off-target binding risks associated with CAR and TCR T cells including, but not limited to, development of the following: – Cell and tissue-based in vitro models that facilitate understanding of T-cell activity against human cells and tissues – Proteomic-scale screening approaches for TCR specificity/off-target activity – Approaches to assess allo-reactivity – Design and conduct experiments to assess genomic changes at the single cell level – Represent Drug Safety Evaluation on cross-functional CAR and TCR T-cell global project teams – Work closely with colleagues in research to identify and address toxicology implications of next-generation therapeutic strategies (gene editing, armoring, etc.) – Participate in the evaluation of new CAR and TCR T-cell targets – Formally communicate research to leadership, project teams, and collaborators – Deliver on short-term project goals while driving innovation that shapes the future of safety evaluation for CAR and TCR T-cell modalities – Prepare technical reports for inclusion in regulatory filings (IND, BLA) – Identify, initiate, and support external academic collaborations – Facilitate and monitor scientific studies conducted at external contract research organizations – Represent BMS externally through publications and presentations at scientific conferences Preferred Experience : – Deep knowledge of T-cell biology, including TCR and peptide/MHC specificity and regulation of T-cell activation and function is essential – Proficiency in laboratory bench skills such as multi-color flow cytometry, cell sorting, ELISAs, Luminex, Mesoscale, western blots, IHC – Proficiency with molecular techniques used for characterizing genomic edits at the single cell level, gene expression analysis and data analysis: qPCr, ddPCR, Amp-Seq, NGS – Culture of primary and immortalized mammalian cells; familiarity with advanced cell culture platforms – Generation of cell lines; generation of CAR-T/TCR-T cells is desirable – Analytical methods for functional characterization of T cells (activation, cytotoxicity, cytokine secretion, proliferation, etc.) – Fluorescence and/or confocal microscopy, live cell imaging and analysis (i.e. Incucyte) – Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale – Familiarity with in vitro and in vivo pharmacology and toxicology models, study design, and conduct would be desirable Qualifications: – Ph.D. in immunology, molecular biology, cancer biology, or related discipline, with at least 2 years of relevant work experience highly preferred. Masters degree with at least 8 years of work experience or Bachelors degree with at least 10 years work experience – Scientific expertise evidenced by strong publication record – Excellent laboratory-based skills in cell and molecular biology – Ability to work independently, in a fast-paced environment – Working knowledge of drug discovery and development process – Track record of supervisory experience with research associates is desirable – Exceptional written and oral communication skills Why You Should Apply: Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.