Scientist, Translational Science, Rheum

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Company :
Johnson & Johnson Family of Companies

Location :
Cambridge, Massachusetts

Expiry Date :
Fri, 26 Mar 2021 23:59:59 GMT

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Description :
Job Details Full-timeEstimated: $110,000 – $140,000 a year3 hours ago Qualifications – Laboratory techniques – Laboratory experience – Cell culture – Clinical trials – Molecular biology – Doctoral degree – Master of Science – Master’s degree Full Job Description Janssen Research and Development, L.L.C., a member of Johnson and Johnson’s Family of Companies, is recruiting for a Scientist, Translational Sciences (TS), Immunology Translational Sciences and Medicine (TSM) to be located in Cambridge, MA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research & Development, LLC discovers and develops innovative medical solutions to ress important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information. Janssen Immunology has a history of bringing life-changing therapies to patients with immune-mediated diseases. Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end to end portfolio. Together, the TSM group will provide the key learnings/insights on the next wave of novel therapies for these patients. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to ress unmet need in immune-mediated diseases. TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision- making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. It has expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development. This position will reside within the Immunology Translational Sciences department and requires a highly motivated and skilled candidate to assist in the clinical progression of innovative therapies across immunologic diseases. The successful candidate will be expected to contribute to the development of drug discovery projects and demonstrate the ability to design, shape, implement novel experiments and interpretation of data. The candidate will bring an enthusiastic discovery mindset to Translational Sciences. The Scientist will be effective in the independent execution and troubleshooting of lab experiments for human-based in vitro/ex vivo stimulation models and new assay development for disease understanding, target validation, and disease exploration. Further, the candidate will operate in a highly collaborative environment with members of TS and the Discovery organization. The Scientist will follow best practices for Data Integrity complying with organization and company standard operating procedures in a timely fashion, such as training and project time accounting. Responsibilities are as follows: Design and execute experiments to discover new biomarkers for portfolio assets Contribute to the strategies on molecular understanding of human diseases, patient stratification and biomarker-based endpoint translational strategies Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution Design, execute, and troubleshoot molecular and/or cellular assays for patient stratification in clinical trials for the Immunology Therapeutic Area Partners with external providers as needed to support development and execution of assays in support of Immunology assets Support new platform development in Immunology Biomarkers Work closely with other lab-based personnel within Biomarkers to ensure optimal laboratory environment (collaboration, culture, safety, etc.) Qualifications PhD with 1-2 or more years of experience or M.S. with at least 5 or more years of relevant experience is required. Experience in pharmaceutical or biotechnology sectors is preferred. Immunologist with a focus in rheumatology and a breadth of lab skills highly is preferred. Fundamental understanding of scientific principles and proven experience in essential laboratory techniques, preferably in a pharmaceutical or biotechnology industry setting is required. Significant experience in handling translational/clinical samples, PBMC processing, isolation of immune cells including T and B cell subsets, serum isolation and cryopreservation is required. Ability to analyze and interpret results and present in clear and organized manner is required. Experience with cellular assays including cell culture experiments for differentiation, proliferation and functional read-outs is required. Proficiency in developing, validating and troubleshooting multi-color flow cytometry panels is required. Experience in immunological assays using ELISA, MSD and/or Singulex platforms is required. Hands-on experience with molecular biology techniques including RNA/DNA isolation, RT-PCR and Gene expression is preferred. Strong ability to work independently and develop new technical skills to meet the needs of a fast-paced environment. Good interpersonal skills and ability to work in a highly matrixed organization. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. IMPACTIMM Primary Location United States-Massachusetts-Cambridge-MA Cambridge Binney Organization Janssen Research & Development, LLC (6084) Job Function R & D Requisition ID W Show full job description Apply Now