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Senior Associate Scientist, Discovery Biology Immune

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Company :
Bristol-Myers Squibb

Location :
Seattle, Washington

Expiry Date :
Mon, 26 Apr 2021 23:59:59 GMT

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Description :
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. The Discovery Biology Team in Immune Oncology and Cell Therapy is looking for a highly motivated and dynamic scientist to join our team and help drive the development of novel immune based anti-cancer therapeutics using cell therapy, small molecule and biologics modalities. The ideal candidate will have a proven technical and scientific track record in immunology and oncology cell based and molecular assay systems and experience working in a multi-disciplinary team environment. They will be excited to learn new technologies and develop novel assay systems to help develop next generation therapeutics. Responsibilities will include but are not limited to: – Independently plan, design, execute, interpret, troubleshoot and report on scientific experiments to enable timely decisions on therapeutic development discovery activities. – Work at the bench to develop and execute novel in vitro and ex vivo immune cell and tumor cell assays for target validation, drug candidate evaluation, mechanistic studies and biomarker development. – Perform cell biology, molecular biology, and biochemical techniques including primary and tumor cell culture, lymphocyte, myeloid cell, and fibroblast activation and characterization assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, and western blotting. – Keep up with latest technological and scientific approaches to Immune-Oncology and Cell Therapy research using literature and other sources. – Collaborate effectively and cultivate positive and productive relationships with other scientists within and outside BMS. – Present to manager, project team and work groups, provide scientifically rigorous review of data and help plan next steps. – Contribute to written invention disclosures, internal and external regulatory reports as needed. – Participate in maintenance of routine laboratory instrumentation and supplies. – Adherence to laboratory safety policies and practices. – May supervise other research associates as needed. Required Qualifications: Bachelors degree in a scientific discipline with at least 6 years work experience or Masters degree with at least 4 years work experience in relevant field of research for Associate Scientist. The most successful applicant will bring a mix of: – Technical experience with and scientific understanding of: – One or more in vitro immune assays including T cell, NK cell, macrophage, DC, Treg, fibroblast – Two or more of the following: Flow cytometry (FACS), cytotoxicity assays, ELISA, ELISpot, microscopy, Luminex, transfection, lentiviral infection, RNA and protein purification and analysis (Taqman and western blot) – Broad understanding of immunology and oncology. – Specific expertise in myeloid and/or fibroblast biology is a plus. – Planning skills to execute on multiple work streams and provide timely and prioritized results. – Trouble shooting and problem-solving skills to resolve technical and scientific questions in a multi-disciplinary, multi-site team oriented environment. – Excellent communication skills working in a team focused multi-site environment. – Ability to work in an environment with changing priorities. Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.