Senior Principal Scientist, Tissue/IHC Biomarker Assays

  • Anywhere

Company :
Bristol-Myers Squibb

Location :
Redwood City, California

Expiry Date :
Sun, 25 Apr 2021 23:59:59 GMT

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Description :
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies. Position Summary: We are seeking a highly motivated and talented individual to join and lead the formed tissue/IHC biomarker team within the Translational Development Group at Bristol Myers Squibb (Redwood City, CA) TME TRC. This team is responsible for all tissue-based biomarker assays from program inception through First in Human studies, in alignment with clinical development objectives, as well as clinic-ready patient selection and pharmacodynamics biomarker assays for the TME TRC programs. The data generated from this team will influence a broad array of decisions from the target validation stage through dose optimization, indication prioritization, and potential drug combinations. The candidate will interact and collaborate with scientists within Translational Development, Clinical Development, Discovery, Translational Bioinformatics, and our external business partners both Academic and CRO. The successful candidate must be able to set and understand priorities in a local and matrixed environment, must be a team player with a collaborative spirit, and capable of building and maintaining networks within and outside the organization. The candidate must have a strong background in tissue-based biomarker assays and their applications in translational/clinical programs as well as experience with and understanding of tumor immuno-oncology related disciplines. Responsibilities will include, but are not limited to, the following: – Lead a group of ~4 – 5 scientists to drive the adaptation, execution, integration and validation of cutting-edge tissue-based assay technologies (e.g. IHC, ISH, Multiplex IF/IHC, spatial transcriptomics) and digital image analysis to develop translational biomarkers in oncology from preclinical through phase 2. – Provide core support for IHC assay development for early programs including antibody screening for optimal IHC reagents – Serve as a subject matter expert in immunohistochemistry and other tissue-based assays development and fit-for-purpose validation – Evaluation of reagents, controls, samples and data (internal and external), including comparisons between methodologies. – Successfully develop and implement novel multiplexed IHC and IF assays for application to slide-based tissues samples to address complex biological challenges across the TME TRC portfolio. – Contribute to development of assays that may progress to patient selection and/or companion diagnostics. – Collaborate closely with scientists from TME-TRC and bioinformatics to customize image analysis workflows to support biomarker analysis for early and late stage programs. – Serve as SME and/or oversee out-sourced (CRO) work packages in support of discovery and translational projects as well as for the strategy and portfolio team supporting early development assets. – Provide input to translational biomarker and clinical sample strategies in relation to tissue-based assay technologies – Develop SOPs, validation plans, final reports, presentations and publications summarizing data. – Effectively collaborate in highly matrixed organization to drive the advancement of therapeutic candidates. – Partner with discovery, preclinical scientists and translational strategy project teams to guide tissue-based assay selection – Actively participate in internal and external scientific meetings through presentations and critical evaluation of both internal results and emerging scientific literature. Qualifications: – PhD, MD, or MD/PhD in biology, pharmacology, or related discipline with at least 8 years of hands on experience in the industry, contract research organization, or pharma setting is required in oncology. – Subject matter expert in the development and validation, troubleshooting and implementation of assays using various advanced technologies that may not be currently in clinical use. – Must have experience with cutting-edge tissue-based assay technologies (e.g. IHC, ISH, Multiplex IF/IHC, spatial transcriptomics) and ability to apply their experience to biomarker development. – Must have extensive experience using digital image analysis software/digital pathology such as Halo, Visiopharm, Aperio systems. – CRO experience, knowledge of CLIA/GCLP practices is a plus, but not required. – Understanding of fit for purpose assay validation principles for clinical assays. – Excellent organization skills and familiarity with a fast-paced work environment. – Collaborative spirit and ability to thrive in a matrixed environment – Prior line management experience – Ability to clearly communicateand operate in a highly matrixed environment – Proven track record of handling multiple high priority tasks in parallel with internal and external collaborators – Excellent written and verbal communication skills and experience with Excel and PowerPoint. – Experience in mentoring scientists, and a proven ability to build an effective organization by attracting, retaining and developing high-caliber scientists. BMSONCRD, BMSDDTMRCA Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.