Senior Scientist Computational Biology

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San Francisco, California

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Wed, 07 Apr 2021 23:59:59 GMT

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Job Details Full-time6 hours ago Qualifications – Immunoassays – Genetics – Assays – Communication skills – Clinical trials – Bachelor’s degree – Doctoral degree – Master’s degree Full Job Description Career Category Research Job Description Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is developing our Translational Science focus with modern molecular and cellular science and pathology laboratories, designed to discover and develop valuable biomarkers in support of clinical programs. The Clinical Biomarkers & Diagnostics (CBD) department at Amgen is looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, ML algorithms & data science, statistical modeling, handling clinical data sets and a background in biology and computational sciences. This is a high-visibility, individual contributor role preferring experience within matrix environments representing the function and requiring the development of methods to support the entirety of the clinical portfolio at Amgen. Responsibilities Support the development of clinical biomarkers supporting Amgen programs through the formulation and execution of biomarker data analysis Perform assessment of biochemical coverage, patient stratification, indication selection in Amgen’s early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques Develop translational informatics analysis methods to enable the analysis of NGS data/Epigenomics assays/single-cell assays from clinical trials Develop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics and epigenomics domains Develop innovative best-practices for the next generation of clinical bioinformatics, such as the utilization of ctDNA-derived tumor burden as a prognostic biomarker/surrogate end point Work with biologists, especially in immuno-oncology, to leverage information on targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics and other high-content databases Provide leadership and expertise to the function in the areas of algorithm development, bioinformatics, data integration & management, visualization, analysis and presentation May represent the clinical biomarkers & diagnostics team in Amgen program/portfolio teams as a biomarker analysis lead Interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics and biomarker representatives Basic Qualifications Doctorate degree and 1 year of scientific experience OR Master’s degree and 3 years of scientific experience OR Bachelor’s degree and 5 years of scientific experience Preferred Qualifications PhD in Bioinformatics, Mathematics, Statistics, Computer Science, Biology A working knowledge of bioinformatics, applied mathematics and/or statistics to analyze multi-modal, multi-dimensional and large-scale biological data sets such as those from GWAS, next-generation sequencing, RNASeq and proteomics assays A working knowledge of platforms and readouts utilized for the assessment of clinical biomarkers including flow cytometry, IHC, NGS, immunoassays, imaging and transcriptional profiling assays Ability to translate biological and medical questions into analytical models providing actionable results Programming experience in Python & R Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers Familiarity with assay development and qualification requirements for clinical trial support Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community Three or more years of relevant experience in the biotech or pharmaceutical industry A strong scientific background with training in genetics and a proven track record of productivity Strong written and oral communication skills, self-motivation, independence and leadership At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our ‘people-first’ philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business. A Fortune 150 company operating in nearly 100 countries around the world, we invest in highly skilled, dedicated and collaborative individuals who are ready to contribute to our mission in meaningful ways and make a difference in the lives of our patients. That’s why, as a member of our cross functional, cross discipline team, we provide you with valuable opportunities to broaden your experience and maximize your potential. Focused on the industry’s most compelling scientific discoveries and housed within industry leading facilities within the heart of the world’s leading biotechnology hub, our colleagues are growing our pipeline through groundbreaking innovations. We believe in rewarding those who do rewarding work and are committed to providing careers that can help turn the tide of serious, life interrupting illnesses. Join Us If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. Apply Now