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Senior Scientist / Scientist, Cancer Immunotherapy

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Company :
Fate Therapeutics, Inc.

Location :
San Diego, California

Expiry Date :
Mon, 26 Apr 2021 23:59:59 GMT

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Description :
Senior Scientist / Scientist, Cancer Immunotherapy Job code 484MH Description Fate Therapeutics is seeking a highly motivated Immunologist with expertise in immune oncology to join a multidisciplinary team dedicated to the discovery of novel cellular therapeutics. The candidate must have in-depth knowledge of NK or T cell biology, with a focus on cell-based therapy and solid tumors. Extensive experience with in vitro functional characterization of NK or T cells is required. Experience with in vivo cell-derived xenograft, patient-derived xenograft, and/or syngeneic tumor models is highly desired. As a member of our cancer immunotherapy team, the successful candidate will provide scientific and technical input for ongoing project initiatives, in addition to executing and overseeing key in vitro and in vivo studies. This is a full-time position reporting to a Principal Scientist, Cancer Immunotherapy and is located at the Company s corporate headquarters in San Diego, California. Responsibilities Execute experiments to test novel iPSC-derived CAR-T cells engineered for solid tumors Perform phenotypic and functional analyses of CAR-T cells using multi-parameter flow cytometry and standard in vitro assays assessing proliferation, cytokine secretion, polyfunctionality, and target cell killing Develop and optimize new in vitro assays to model various aspects of a solid tumor microenvironment and test iPSC-derived CAR-T cell function Coordinate and oversee in vivo studies and ex vivo analyses of iPSC-derived CAR-T cells Ensure consistent progress toward achieving team objectives and timelines Explore new areas of research in cell-based immunotherapy for solid tumors Prepare data packages and present to immunology groups and larger program-specific teams or external collaborators Qualifications Ph.D. degree in Immunology, cancer biology, or other related fields with a minimum of five years of relevant post-doctoral and / or industry experience Strong ability to design, develop and implement novel in vivo xenograft and/or syngeneic tumor models Excellent working knowledge of standard immunology assays used to characterize T and/or NK cells Expertise in multi-color flow cytometry, including intracellular staining Experience with transfection, or lentiviral transduction of primary immune cells is desirable Experience with xCelligence or IncuCyte platforms is desirable Experience with spheroid assays is a plus Proven ability to coordinate with multiple researchers for scheduling and execution of complex experiments Excellent organization skills and ability to multitask Strong communication, writing, and presentation skills Positive outlook, willingness to learn, and a team-oriented attitude People management skills a plus Working Conditions and Physical Requirements Will require working with cells and cell lines of human and/or animal origin Will require working with hazardous materials 100% on-site work at corporate headquarters in San Diego, CA Evening and weekend work as necessary The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time. For consideration send cover letter and resume to: and reference job code 484MH. About Fate Therapeutics, Inc. Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company s immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). The Company s pipeline also includes ProTmune , a pharmacologically modulated, donor cell graft that is currently being evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease in patients with hematologic malignancies undergoing allogeneic stem cell transplant. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit .