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Sr. Assoc. Scientist / Scientist I DMPK

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Company :
Biogen

Location :
Cambridge, Massachusetts

Expiry Date :
Mon, 26 Apr 2021 23:59:59 GMT

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Description :
Job Details Full-timeEstimated: $120,000 – $150,000 a year4 hours ago Qualifications – Microsoft Excel – Cell culture – Communication skills – Clinical development – Laboratory information management systems – Bachelor’s degree – Doctoral degree – Master’s degree Full Job Description Job Description Biogen is seeking a highly motivated, results driven Senior Associate Scientist/Scientist 1 to join the Drug Metabolism and Pharmacokinetics (DMPK) department at our Kendall Square site in Cambridge, Massachusetts. In this role, the candidate will scientific expertise to the discovery and non-clinical development of small molecule therapeutics by carrying out critical path in vitro ADME assays. He/she will be primarily responsible for conducting, optimizing, and troubleshooting ADME screening assays, in particular transwell permeability (MDR1/MDCK and BCRP), to evaluate new chemical entities across the discovery project portfolio. He/she will directly impact the direction of active therapeutic projects and contribute to building in silico predictive models to improve our compound design. The core responsibilities of this position are to: Maintain cell cultures for mammalian cell-based assays Conduct high throughput ADME screening assays using Tecan and Hamilton automated liquid handlers and state-of-the-art HT LC/MS analytical systems Conduct, analyze, interpret, and document (in electronic notebook) ADME studies and communicate ADME screening study results to internal stakeholders In ition to the core responsibilities, the role will allow for itional opportunities such as CRO interactions, contribution to scientific reports, evaluation of emerging in vitro and in silico tools, contribution to the implementation of new assays/techniques, authorship of scientific papers and presentations at scientific meetings where appropriate. You will join a fast paced, collaborative, and strong scientific community at Biogen deeply committed to scientific excellence in developing life-changing therapies for unmet medical needs. Qualifications Requirements: Senior Associate Scientist level: – Bachelor’s degree in scientific discipline plus 4-6 years of experience – Master’s degree in scientific discipline plus 2-4 years Scientist I level: – Bachelor’s degree in scientific discipline plus 6-8 years of experience – Master’s degree in scientific discipline plus 4-6 years – PhD plus 0-2 years of experience Basic Qualifications: Accomplished in the use of Microsoft Excel, Word, and PowerPoint Experience with mass-spectrometry based analysis (high throughput LC/MS) Effective oral and written communication skills are essential Utilizing applications to upload data to LIMS systems Preferred Qualifications include: Experience in cell culture handling Experience with transwell permeability assays Experience with TECAN and Hamilton automation Previous skills working with High Throughput front-ends such as the RapidFire, A, or multiplexing Familiarity with programming in Excel/VB or Pipeline Pilot Critical and proactive thinking and experience in drug discovery and/or development; expertise with implementing, optimizing and troubleshooting in vitro transporter assays; and demonstrated ability to communicate with team members across broad disciplines. Candidate will be hired at level commensurate with experience. itional Information All your information will be kept confidential according to EEO guidelines. Apply Now