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Sr. Principal Scientist, Respiratory Infections Biomarkers

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Company :
Johnson & Johnson Family of Companies

Location :
San Francisco, California

Expiry Date :
Mon, 07 Dec 2020 23:59:59 GMT

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Description :
Job Details Full-timeEstimated: $100,000 – $140,000 a year2 hours ago Qualifications – Communication skills – Data analysis skills – Research – Doctoral degree Full Job Description The Infectious Diseases Biomarker group is recruiting for a Senior Principal Scientist Respiratory Infections Biomarkers, located in South San Francisco, CA or Beerse, Belgium. At Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research & Development discovers and develops innovative medical solutions to ress important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information. We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer. The Infectious Diseases (ID) Therapeutic Area of Janssen R & D is pioneering new treatment paradigms and has various assets in late discovery and clinical development. The ID Biomarkers team develops and executes on strategies that identify and implement novel biomarkers that aim to improve our understanding of the disease and of treatment efficacy and safety in late discovery and early clinical trials, to support clinical proof of relevance of novel treatment modalities, and to effectively enable stratification of patient segments according to disease subtypes and medical need. Responsibilities In collaboration with respiratory infections discovery and early development teams, take the lead to develop and execute upon evolving biomarker plans for novel treatment assets at late stage of discovery research that will be part of the information package that supports the transition of an asset towards early development. Describe the biomarker needs in projects and propose the most appropriate technical-scientific approaches that can ress these specific needs. Ensure optimal collection of samples for biomarker research in experimental study designs that subsequently allows application of appropriate and fit-for-purpose methods with the aim to identify relevant biomarkers from pre-clinical data and to design approaches to translate these biomarkers to clinical application in the targeted diseases. Responsible for the generation, analysis, interpretation and reporting of high dimensional biomarker data on samples collected in the context of discovery, translational research or early clinical studies on respiratory infectious diseases. Be actively engaged in participating and evaluating progress in collaborative programs with external partners on biomarker research in respiratory infection diseases aiming to develop novel insights into disease biology or prognosis and/or options for patient segmentation. Combine solid respiratory infections disease knowledge with data analysis and statistical expertise to characterize disease mechanisms and elucidate mode of action for novel therapeutic options. Drive integrative analysis and interpretation of high-dimensional biomarker data generated in the projects from a variety of platforms including next-generation sequencing, gene expression profiling, proteomics, flow cytometry, microbiome analysis and digital readouts (eg, from multisensors). Collaborate with other scientists from ID Biomarkers, Computational Sciences, Data Sciences, Quantitative Sciences, and R & D IT to implement data analysis approaches that ress the biomarker needs in particular for the respiratory infections discovery programs. Communicate and report (oral and written) on the scientific progress of biomarker research in the respiratory infections discovery and development programs. Qualifications PhD in translational sciences, ideally with experience in biomarker research. Solid knowledge of immunology is required, and preferably also on infectious disease biology. At least 10 years relevant postdoctoral experience in an academic or industrial research environment. Hands-on experience with multiple high-dimensional omics platforms (eg, NGS, transcriptomics, flow cytometry, cell sorting, …). Proficiency with high-dimensional biomarker data analysis tools and software. Scientifically critical and creative mindset that identifies knowledge gaps in projects that may be related to lack of good biomarkers, and be able to propose actionable strategies that may ress these gaps. Ability to work independently and develop new technical or data analysis skills to meet the needs of a fast-paced environment. Excellent communication skills, collaborative mindset and team player, willingness and flexibility to work in a highly-matrixed organization required. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Primary Location United States-California-South San Francisco- Other Locations Belgium-Antwerp-Beerse Organization Janssen BioPharma, Inc. (6224) Job Function R & D Requisition ID W Show full job description Apply Now