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Sr. Scientist, Medicinal Chemistry

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Company :
Calithera Biosciences

Location :
South San Francisco, California

Expiry Date :
Sat, 19 Dec 2020 23:59:59 GMT

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Description :
Senior Scientist / Medicinal Chemistry Calitihera is seeking a talented and highly motivated chemist with pharmaceutical industrial experience to join our chemistry team. As a Senior Scientist, the successful candidate will contribute to all phases of the drug discovery, including HTS, hit identification, hit to lead, lead optimization and candidate nomination. As a member of a dynamic multiple disciplinary team, the candidate will collaborate with a broad group of scientists within Calithera and external groups to identify new molecular entities to transform patients lives. Background: Calithera Biosciences is a clinical-stage biopharmaceutical company pioneering the discovery and development of targeted therapies that disrupt cellular metabolic pathways to preferentially starve tumor cells and enhance immune-cell activity. Driven by a commitment to rigorous science and a passion for improving the lives of people impacted by cancer and other life-threatening diseases, Calithera is advancing a pipeline of first-in-clinic, oral therapeutics to meaningfully expand treatment options available to patients. Calithera is headquartered in South San Francisco, California. Primary Responsibilities: * Design novel bioactive chemical entities in alignment with project goals based on the SAR analysis and by applying medicinal principles and tools. * Plan and execute the synthesis, purification, and characterization of complex small molecules. * Employ sound judgment in the evaluation and strategic decision making on HTS hits and subsequent hit optimization follow-up. * Advance drug discovery programs by collaboratively interacting with other cross-functions to understand and optimize DMPK and in vitro and in vivo pharmacological properties. * Effectively manage and mentor junior medicinal chemistry colleagues and external CRO chemists through strong synthetic and medicinal chemistry skills. * As needed, contribute to chemistry program strategy or serve as chemistry project lead for drug discovery programs. * Work closely with biologists to evaluate new programs and provide input on chemical tractability and analysis of literature leads. * Present results of work, interprets data, and draws conclusions regarding presented material and nature of work. * Contribute effectively to patent, report and scientific publication writing. Requirements: * Ph.D. in synthetic organic chemistry or medicinal chemistry with 5- 8 years pharmaceutical industrial experience in small molecule drug discovery and development. * Excellent understanding of medicinal chemistry concepts and execute strategies across all stages of drug discovery process to achieve program goals. * Proven track record in medicinal chemistry as evidenced by successful advancement of drug discovery projects is desirable. * Good understanding with structure-based drug design concept is desirable. * Exceptional understanding of physicochemical, ADME, biochemical, pharmacology principles and effectively applying these in the design of novel small molecule drugs and toward successful project advancement. * Demonstrate a high level of creativity and productivity with strong synthetic problem-solving skills. Have clear command of organic synthesis and conversant with the current literature. * Experience in mentoring and managing both internal junior chemists and external chemistry resources. * Collaborate and communicate across a dynamic multi-disciplinary scientific team to successfully progress scientific goals. * Excellent written and oral communication skills including ability to present the rationale, data, issues and accomplishments of the team. Calithera Biosciences, Inc. is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status. To learn more information about this position: Privacy Notice for California Candidates California law requires that we provide you this notice about the collection and use of your personal information. We encourage you to read it carefully. Effective Date: October 13, 2020 Introduction This notice ( Notice ) describes the categories of personal informatio that Calithera Biosciences, Inc. ( Company , we , us our ) collects about California residents who apply or are recruited job with us or one of our affiliates ( candidates ), and the purposes which we use that information. For purposes of this Notice, personal information has the meaning gi in the California Consumer Privacy Act of 2018 (the CCPA ) but exclud information exempted from the CCPA’s scope. This Notice does not create or form part of any contract for employment or otherwise. If you have questions about this Notice, please contact . Calithera’s privacy policy can be found online at privacy-policy/. Information we collect about candidates 1.1. Categories of personal information The categories of personal information we may collect and process during the application and recruitment process include: * Contact information, such as home address, telephone number, and email address; * Information from job application materials or recruiters, such as your job application, resume or CV, cover letter, writing samples, references, work history, education transcripts, whether you are subject to prior employer obligations, and information that referrers provide about you; * Professional qualifications, such as licenses, permits, memberships, and certifications; * Information from the application process, such as any phone-screens, interviews, evaluations and outcomes of recruiting exercises; * Immigration status and other information that would allow us to verify your employment eligibility; * Biographical information, such as name, gender, date of birth, professional history, references, language proficiencies, education details, and information you make publicly available through job search or career networking sites; * Job preferences, such as desired position and compensation, location preferences and willingness to relocate; * Employment history; * Background check information, such as information necessary to complete background, credit, drug/alcohol and/or other checks when permitted by law, and information received during these checks; * Information needed to understand and assess accommodation requests regarding potential disabilities or other health conditions; * Internet or other electronic network activity information, including, but not limited to, browsing history, search history, and information regarding an applicant’s interaction with an internet website, application, or advertisement, as well as physical and network access logs and other network activity information related to your use of any Company device, network or other information resource. * Characteristics of protected classifications under California or federal law, such as race, color, sex, gender identity, national origin, and military/veteran status; * Audio, electronic, visual and similar information, such as CCTV footage, photographs, and audio, video or call recordings created in connection with our business activities; and * Other information you provide to us. Providing personal information to us is voluntary. However, if you do not provide sufficient information, we may be unable to consider your application or, if you are hired, your subsequent promotion, transfer or relocation. In certain cases, we may ask you for additional information for purposes of complying with applicable laws. We may also inquire about criminal records. We will do so only where permitted by applicable law. How we use personal information about candidates 2.1. Purposes for which we use personal information We may use the categories of personal information above for the following purposes: * Recruitment management. Managing recruitment generally, such as: o operating the careers website that we maintain at https:// or any other site to which this Notice is posted ( Careers Site ); o recruiting, interviewing and evaluating job candidates; o conducting background checks or other pre-employment screening (where permitted by law); o extending offers, negotiating the terms of offers, and assessing salary and compensation matters; o analyzing and improving our application and recruitment processes; o accommodating disabilities or health conditions; o communicating with you regarding your candidacy, opportunities with the Company or about the Careers Site and any changes to applicable terms or policies; o maintaining your personal information for future consideration; and o other business operations. * Compliance, safety and fraud prevention, such as: o complying with or monitoring compliance with legal and other requirements, such as reporting and equal opportunities monitoring requirements, where applicable; o complying with internal policies and procedures; o complying with lawful requests and legal process, such as responding to subpoenas or requests from government authorities; o protecting our, your or others’