Sr. Scientist, Structural Biologist (Cryo EM and X ray crystallography)

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South San Francisco, California

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Tue, 06 Apr 2021 23:59:59 GMT

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Job Details Full-timeEstimated: $110,000 – $170,000 a year4 hours ago Benefits – Health insurance Qualifications – Driver’s License – Communication skills – Hazmat Endorsement – Project management – Data collection – Doctoral degree Full Job Description Job Description Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough. This position within the Computational and Structural Sciences Department at Our Company’s Research Laboratories (South San Francisco, CA USA) will support drug discovery through the use of atomic resolution single-particle cryo-EM and x-ray diffraction to determine the structure of therapeutically important targets.The successful candidate will join our growing structural biology team and be responsible for all aspects of the structural biology process, from sample preparation and data collection through data processing and structure determination and will work in collaboration with medicinal and computational chemists.The successful candidate willwork closely with molecular biologists, biochemists, and biophysicistsfor sample optimization. Productive and collaborative interactions with other members of the global, cross-functional department are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal expertise and resources will be essential to success.The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings. Consistently cited as a great place to work, our company employs talented people who discover, develop, manufacture and market a wide range of vaccines and medicines to ress unmet medical needs. Each of us is joined by an extraordinary sense of purpose – bringing our company’s finest achievements to people worldwide. The South San Francisco campus is located within the heart of the industry in the Bay Area.This close proximity allows for close interactions with the quickly expanding high-resolution single-particle cryo-EM community as well as the structural biology field at large, giving easy access to the latest developments in the field. Education Minimum Requirement: Candidates for this position must have a Ph.D. Required Experience and Skills: PhD degree in the structural biology field. Demonstrated experience in a broad range of activities for atomic resolution single-particle cryo-EM and x-ray crystallography, including sample preparation, data collection, image processing & structure determination. Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required. Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in structural biology. Ability to work effectively and flexibly within timelines. Ability to prepare peer-reviewed publications. Preferred Experience and Skills: PhD degree with at least two years of postdoctoral training in the structural biology field. Experience with biophysical and functional characterization methods (e.g. Surface Plasmon Resonance ( SPR), Nuclear Magnetic Resonance (NMR), thermal shift and colorimetric assays) to guide construct design and optimization of solution conditions for successful structural outcomes Experience with structure determination of antigen: antibody complexes. Experience with structure determination of small molecule protein complexes Experience with the application of hybrid structural techniques to answer biological questions Ability to manage multiple projects and subsequent prioritization Experience using computational tools for protein engineering and design We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we ‘follow the science’ and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are … We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world’s most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world. What we look for … In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth. INVENT. IMPACT. INSPIRE. NOTICE FOR INTERNAL APPLICANTS In accordance with Managers’ Policy – Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior toing for open positions. If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor. US and Puerto Rico Residents Only: If you need an accommodation for the application process please email us at For more information about personal rights under Equal Employment Opportunity, visit: EEOC Poster EEOC GINA Supplement OFCCP EEO Supplement OFCCP Pay Transparency Rule We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations. Search Firm Representatives Please Read Carefully Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: No Travel Requirements: 10% Flexible Work Arrangements: Shift: Valid Driving License: Hazardous Material(s): Number of Openings: 1 Requisition ID:R Job Information Job ID: Location: South San Francisco, California, United States Position Title: Sr. Scientist, Structural Biologist (Cryo EM and X-ray crystallography) Company Name: Merck Job Function: Other Job Type: Full-Time Show full job description Apply Now