Website Abacus Service Corporation
Abacus Service Corporation
Company : Abacus Service Corporation
Description:
Scientist I, Oligonucleotide Analytics
LOCATION: LA JOLLA, CALIFORNIA (NOT NEW JERSEY)
Key Responsibilities:
30% " Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% " Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis
10% " Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% " Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% " Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
" Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
" Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% " Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% " Ensure the supply of laboratory consumables and reagents are in stock as needed
" Maintain a high level of productivity in the laboratory setting.
2% " Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
" Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
" Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems – Analyze and optimize methods – establish and automate high throughout analytical capabilities
Role is 100% onsite
Enable Skills-Based Hiring
No
Is this position safety sensitive?
No
Will this position require the handling of a controlled substance?
No
Funding or Grant Tracking
No external funding
Hours per Day
8
Hours per Week
40
Total Hours
2,088.00