Website The Fountain Group LLC
The Fountain Group LLC
Company : The Fountain Group LLC
Currently seeking a Scientist for a prominent client of ours. This position is located in South San Francisco, CA. Details for the position are as follows:
Pay: $55 – $59 per hour
Duration:6 months + potential extension
- Seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group.
- The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for Client biologics entities.
- The successful candidate will be experienced in the development, optimization and implementation of Client and routine LC/MS-based bioanalytical methods to support in vivo PK, TK, and PK/PD studies as well as in vitro stability characterization of therapeutic proteins, peptides, and oligonucleotides.
- The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.
Key tasks and responsibilities:
- Operate and maintain LC/MS instruments to generate high-quality experimental data.
- Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
- Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
- Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
- Communicate data interpretation internally and externally.
Qualifications:
Degree in chemistry, pharmacology or other related fields. BS/MS with 1 year of LC-MS (QQQ) experience or a fresh PhD with the right LC-MS experience, in a pharmaceutical industry setting with a focus on mass spectrometry.
- Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
- Prior industry experience in drug discovery/development is preferred. In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired.
- Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is highly desired.
- Hands-on experience with automated liquid handling systems is highly desired.
- Hands-on experience with oligonucleotide analysis is highly desired.
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